{"id":"W2138733479","doi":"10.1158/1055-9965.epi-11-0775","title":"Pathology of Breast and Ovarian Cancers among <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Results from the Consortium of Investigators of Modifiers of <i>BRCA1</i> / <i>2</i> (CIMBA)","year":2012,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":668,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"National Institute for Health and Care Research; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; ZonMw","keywords":"Medicine; Ovarian cancer; Mutation; Oncology; Gynecology; Internal medicine; Breast cancer; Pathology; Biology; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002190701,0.0002691727,0.0006774921,0.00009454116,0.0000718519,0.000002683862,0.000238235,0.000432579,0.000009881892],"category_scores_gemma":[0.0008273613,0.0002375604,0.0001699307,0.0002415178,0.002772525,0.00003527401,0.0001450793,0.0001469432,1.383981e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008506695,"about_ca_system_score_gemma":0.0004281897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002716009,"about_ca_topic_score_gemma":0.000694564,"domain_scores_codex":[0.9966418,0.0009937382,0.001317294,0.0005399219,0.0001421021,0.000365102],"domain_scores_gemma":[0.9967213,0.0005122174,0.001785337,0.0005706537,0.0002597992,0.0001507498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00136895,0.0000786674,0.6229827,0.0002038537,0.001421499,7.338268e-7,0.001570742,0.0005889321,0.3587164,0.0004334263,0.003963906,0.00867023],"study_design_scores_gemma":[0.003962922,0.000465676,0.6984388,0.0004232113,0.0007886721,0.00004372004,0.001917124,0.0003024672,0.2895946,0.002472525,0.001148697,0.0004415954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724419,0.023305,0.001353572,0.0006157937,0.000555443,0.0004958052,0.001101521,0.000007446272,0.0001235555],"genre_scores_gemma":[0.9941346,0.002517383,0.002485543,0.0002559478,0.0001282002,0.00008164748,0.0003460905,0.00002794283,0.0000226586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07545612,"threshold_uncertainty_score":0.9999413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657724511671087,"score_gpt":0.2983575389616172,"score_spread":0.2717802938449063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}