{"id":"W2138733479","doi":"10.1158/1055-9965.epi-11-0775","title":"Pathology of Breast and Ovarian Cancers among <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Results from the Consortium of Investigators of Modifiers of <i>BRCA1</i> / <i>2</i> (CIMBA)","year":2012,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":668,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"National Institute for Health and Care Research; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; National Institutes of Health; ZonMw","keywords":"Medicine; Ovarian cancer; Mutation; Oncology; Gynecology; Internal medicine; Breast cancer; Pathology; Biology; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002210761,0.0003390244,0.0003963065,0.001778801,0.0003136287,0.000552894,0.0004785754,0.0005071594,0.00108592],"category_scores_gemma":[0.00577386,0.0002442188,0.0005665781,0.00107138,0.0003468925,0.0003512909,0.00062588,0.0003557196,0.0002060512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000420504,"about_ca_system_score_gemma":0.0002860397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008136029,"about_ca_topic_score_gemma":0.007536327,"domain_scores_codex":[0.9988092,0.000287984,0.0001058882,0.0004743775,0.0002306649,0.00009199476],"domain_scores_gemma":[0.9943144,0.001893103,0.002258609,0.0005118417,0.0004743363,0.0005476489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003605719,0.000009760104,0.9980557,0.00001476092,0.0001357913,0.00002755566,0.0000394399,0.00002299167,0.000226901,0.000006174446,0.00008354031,0.00101694],"study_design_scores_gemma":[0.00001055452,0.00004105306,0.9994956,0.00000394146,0.00006769157,0.000131954,0.0000408003,0.00003054126,0.00006661664,0.000006922546,0.000102565,0.000001754157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974977,0.0007584994,0.00008183036,0.00002494426,0.000002784182,0.00001133722,0.001407405,0.00000503225,0.0002105183],"genre_scores_gemma":[0.9974422,0.0002385494,0.0001246488,0.00002354806,0.000006823544,0.00001400152,0.002044408,0.000005232985,0.0001005665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008136029,"threshold_uncertainty_score":0.01617736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657724511671087,"score_gpt":0.2983575389616172,"score_spread":0.2717802938449063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}