{"id":"W2138743983","doi":"10.1074/jbc.m109.071639","title":"Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"RNA polymerase III; Transcription (linguistics); Biology; PI3K/AKT/mTOR pathway; Cell biology; RNA polymerase; RNA polymerase II; Repressor; RNA; Molecular biology; Biochemistry; Chemistry; Transcription factor; Gene; Gene expression; Signal transduction; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007811595,0.0002656833,0.0002628639,0.0001698512,0.0001905801,0.0004334645,0.0001358832,0.000166334,0.0007349247],"category_scores_gemma":[0.00008560211,0.0001128564,0.0002176482,0.0001502701,0.0001733834,0.0001254899,0.0001508891,0.000268974,0.000415679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004251566,"about_ca_system_score_gemma":0.0003552045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001872492,"about_ca_topic_score_gemma":0.00265371,"domain_scores_codex":[0.9999096,0.00001172064,0.0000125934,0.00002394986,0.00002557919,0.00001647337],"domain_scores_gemma":[0.9999545,0.000005925061,0.00001347494,0.000006269527,0.000007424607,0.00001245601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007152919,0.000009821621,0.0001830206,0.00003317397,0.000004719554,0.00003264387,0.0000055695,0.00005390323,0.998292,0.0001029222,0.00003701523,0.001173555],"study_design_scores_gemma":[0.00001532269,0.0001165326,0.01254358,0.000006853386,0.00001636143,0.0002603876,0.00001975543,0.001150657,0.9811245,0.00005679049,0.004683721,0.000005500174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788463,0.01439843,0.002651559,0.0002558978,0.00006508133,0.000042363,0.0008947041,0.0001661438,0.002679505],"genre_scores_gemma":[0.992725,0.002558964,0.001923013,0.00005890473,0.00001248054,0.00003841241,0.001043827,0.00001454324,0.001624795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872492,"threshold_uncertainty_score":0.003723145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640229422877667,"score_gpt":0.2610825971242627,"score_spread":0.244680302895486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}