{"id":"W2138761399","doi":"10.1158/1535-7163.mct-06-0169","title":"Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice","year":2006,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Metastasis; Angiogenesis; Cancer research; Matrix metalloproteinase; Small interfering RNA; Lung cancer; Matrix metalloproteinase inhibitor; Biology; Tumor progression; RNA interference; Extracellular matrix; Gene silencing; Cancer; Medicine; Pathology; RNA; Cell culture; Transfection; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000142972,0.0003095787,0.000265588,0.0001103218,0.00006147788,0.00006130286,0.0002303323,0.0001429162,0.00001100785],"category_scores_gemma":[0.00001792451,0.000309973,0.0001043716,0.000184861,0.00006913054,0.00001087223,0.0001575164,0.0001770941,0.000002138601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003815805,"about_ca_system_score_gemma":0.00008240543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000333724,"about_ca_topic_score_gemma":0.0001976981,"domain_scores_codex":[0.9985041,0.0001130179,0.0003222639,0.0004899177,0.0001627401,0.0004079399],"domain_scores_gemma":[0.9994703,0.0000106056,0.0001150573,0.0002632266,0.00006685532,0.00007394367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124505,0.00006691692,0.0002579184,0.00008160907,0.0001623486,0.00006929765,0.0000249096,0.0000758357,0.9982547,0.0001456334,0.00002581598,0.0007225216],"study_design_scores_gemma":[0.0008548509,0.0001127251,0.00008204775,0.00005785655,0.0001065434,0.000009957441,0.00003147283,0.0003395159,0.995285,0.0002439889,0.002508044,0.0003679559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626169,0.03195207,0.004267889,0.0001931154,0.0001184676,0.0004500225,0.00007609411,0.00003008053,0.0002953705],"genre_scores_gemma":[0.9959711,0.0009803588,0.001424422,0.001117586,0.0001224085,0.0001632029,0.0001022042,0.00006913985,0.0000495152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03335427,"threshold_uncertainty_score":0.9999352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093580398307065,"score_gpt":0.24499564020018,"score_spread":0.2340598362171093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}