{"id":"W2138771949","doi":"10.1124/dmd.30.12.1431","title":"Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)","year":2002,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Chemistry; Stereochemistry; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156324,0.0004113543,0.00035325,0.0002542218,0.000216884,0.0003780253,0.0002751133,0.0005092174,0.002622304],"category_scores_gemma":[0.0001846692,0.0002171666,0.0002865621,0.000120612,0.0003130599,0.0002947839,0.0003081641,0.0004171596,0.001517165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005944009,"about_ca_system_score_gemma":0.0003887579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280497,"about_ca_topic_score_gemma":0.001269989,"domain_scores_codex":[0.9997775,0.00002908785,0.00001286003,0.00008683242,0.00003355605,0.00006016903],"domain_scores_gemma":[0.9998655,0.0000287755,0.00003011428,0.00001507249,0.0000274709,0.00003300733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003516298,0.0001297002,0.00300848,0.0001235334,0.00002720575,0.0002529127,0.00005837198,0.000196742,0.975379,0.001724737,0.0005487082,0.01819896],"study_design_scores_gemma":[0.00002318633,0.0002289247,0.00568295,0.000007644919,0.00001185198,0.001013481,0.00005687426,0.0009508487,0.9832355,0.000372004,0.008405551,0.0000112233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8864702,0.02467232,0.05898218,0.001656096,0.0007403655,0.0003408718,0.002790828,0.0009341516,0.02341298],"genre_scores_gemma":[0.9837291,0.002514702,0.005916202,0.0001286677,0.00005958673,0.00003167136,0.001110089,0.00003325119,0.006476711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002622304,"threshold_uncertainty_score":0.008772492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006956975050223802,"score_gpt":0.2038295923436013,"score_spread":0.1968726172933775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}