{"id":"W2138783723","doi":"10.1152/ajpheart.01247.2005","title":"Decrease in density of <i>I</i><sub>Na</sub> is in the common final pathway to heart block in murine hearts overexpressing calcineurin","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Calcineurin; Internal medicine; Endocrinology; Ryanodine receptor; Sudden death; Sodium channel; Medicine; Chemistry; Sodium; Calcium; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760233,0.0004270994,0.0004610316,0.0005305181,0.0001464034,0.0003433714,0.0003177825,0.000517149,0.00195153],"category_scores_gemma":[0.0001510038,0.0002678245,0.0003259749,0.0001434763,0.0003839149,0.0003805509,0.0003190895,0.0009808041,0.0006899633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462099,"about_ca_system_score_gemma":0.0001382996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004671298,"about_ca_topic_score_gemma":0.0006172118,"domain_scores_codex":[0.9997545,0.00002089751,0.00003361101,0.00006046199,0.00006749719,0.00006303495],"domain_scores_gemma":[0.9994697,0.0000431863,0.0001912794,0.00004318849,0.00005815505,0.0001945963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005559248,0.000009894909,0.0001703347,0.00001284317,0.000002771566,0.00003720096,0.000009974305,0.000009199913,0.999385,0.00003051462,0.00001260935,0.0002640381],"study_design_scores_gemma":[0.00001650301,0.0003441355,0.02371919,0.000009162429,0.00001890699,0.0004776185,0.00003880951,0.0004913466,0.9737897,0.00006027369,0.00102856,0.000005891836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922881,0.001444136,0.003144523,0.0001170328,0.00002991104,0.00003286692,0.0004842779,0.0002243668,0.002234811],"genre_scores_gemma":[0.9903001,0.0008597858,0.002943785,0.0001209825,0.00002087478,0.0000807344,0.0007987319,0.0001106016,0.004764434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195153,"threshold_uncertainty_score":0.006528497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050327503068794,"score_gpt":0.2422841529919872,"score_spread":0.2317808779612993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}