{"id":"W2138822762","doi":"10.1172/jci64704","title":"PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Cytotoxic T cell; DNA vaccination; Virology; Antigen; CD8; Biology; Vaccination; Vaccinia; Immunology; Cross-presentation; T cell; Immunity; Antibody; Immunization; Immune system; MHC class I; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001877453,0.0001760426,0.0005990239,0.0002433277,0.00008216883,0.0000377133,0.0003074729,0.000379672,0.001079738],"category_scores_gemma":[0.000723179,0.000138723,0.0002611588,0.0002142634,0.0002589214,0.0003578331,0.00002459948,0.0008681454,0.0008906942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003812148,"about_ca_system_score_gemma":0.0002174397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003523865,"about_ca_topic_score_gemma":0.000004293086,"domain_scores_codex":[0.9966323,0.0008504604,0.001998147,0.0001794075,0.00007632646,0.0002634073],"domain_scores_gemma":[0.9966367,0.001766604,0.001041507,0.0002183946,0.000285567,0.00005119658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009449715,0.0002325744,0.009574558,0.00001318489,0.00008352005,0.000005738564,0.0001781558,0.00006445904,0.956328,0.0001209245,0.02734866,0.005105217],"study_design_scores_gemma":[0.006769371,0.0009675051,0.2047905,0.000293241,0.00003716296,0.0000536652,0.0002141387,0.00003463199,0.704617,0.002305884,0.07964262,0.0002742733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991521,0.003192403,0.0003177126,0.002997128,0.001634196,0.0001966596,0.000004058211,0.00001655162,0.0001202788],"genre_scores_gemma":[0.9954793,0.0007633097,0.0008673107,0.001302183,0.0001681886,0.000007048254,0.00002101902,0.00001948689,0.001372183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.251711,"threshold_uncertainty_score":0.9998872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04905012180690572,"score_gpt":0.3121046314346811,"score_spread":0.2630545096277754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}