{"id":"W2138850044","doi":"10.1091/mbc.e07-07-0662","title":"Munc18-1 Is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Cell biology; Biology; Vesicle; Secretion; Mutant; Secretory Vesicle; Transfection; Subcellular localization; Vesicular transport protein; Membrane protein; Membrane; Cell culture; Biochemistry; Gene; Cytoplasm; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270167,0.0003863248,0.0004895248,0.0003248887,0.0004294848,0.0005378653,0.0005114402,0.0003390506,0.001030458],"category_scores_gemma":[0.0001860902,0.0002281551,0.0003926774,0.0002912237,0.0002368881,0.0002607101,0.0003283569,0.0005754226,0.0007040137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008580867,"about_ca_system_score_gemma":0.0005358559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006402156,"about_ca_topic_score_gemma":0.005518651,"domain_scores_codex":[0.9996864,0.00002422962,0.00005126908,0.00006550552,0.0001030926,0.00006962554],"domain_scores_gemma":[0.9997839,0.00002748365,0.00004481427,0.00003283688,0.0000437119,0.00006721083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000118489,0.00002455095,0.000293218,0.00006188471,0.000007724778,0.0001474028,0.00003815334,0.00006336025,0.998376,0.0001115674,0.00006674323,0.0006908434],"study_design_scores_gemma":[0.0000155671,0.0001098184,0.0107075,0.00001308369,0.00002988899,0.0004399301,0.00008123849,0.001340261,0.9820715,0.00005922893,0.005120087,0.00001198613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992762,0.001939477,0.002220817,0.0001577249,0.00006150611,0.00002606392,0.001245018,0.0001664914,0.001420798],"genre_scores_gemma":[0.9863575,0.001769434,0.003364623,0.00006444127,0.00001330322,0.00008867066,0.002862403,0.00006483165,0.005414819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006402156,"threshold_uncertainty_score":0.01272982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007456996549940687,"score_gpt":0.2438146022176005,"score_spread":0.2363576056676598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}