{"id":"W2138871107","doi":"10.1056/nejmoa1402584","title":"Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis","year":2014,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":4611,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Genentech; Shionogi; Imperial College London; National Institute for Health and Care Research; Veracyte; Galecto; Massachusetts Medical Society; Royal Brompton and Harefield NHS Foundation Trust; University Hospital Southampton NHS Foundation Trust; Gilead Sciences; FibroGen; Biogen; Ikaria; Celgene; Sanofi; Amgen; Pfizer; GlaxoSmithKline","keywords":"Nintedanib; Medicine; Idiopathic pulmonary fibrosis; Placebo; Exacerbation; Vital capacity; Internal medicine; Clinical endpoint; Gastroenterology; Clinical trial; Pathology; Lung; Lung function","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003246314,0.0005253913,0.001600714,0.000237686,0.0002108664,0.0004107434,0.0004772625,0.0008114734,0.002011918],"category_scores_gemma":[0.003435326,0.000228632,0.0009676158,0.0002104869,0.000754185,0.0003676052,0.0002803072,0.001178693,0.0002852064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005014302,"about_ca_system_score_gemma":0.000499715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001763939,"about_ca_topic_score_gemma":0.0003379036,"domain_scores_codex":[0.9986569,0.0008207972,0.0001306527,0.0001257764,0.0001968414,0.00006915448],"domain_scores_gemma":[0.9982217,0.0007893688,0.0005236301,0.00008498839,0.00009626884,0.0002840443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7648343,0.005801652,0.008841841,0.002152327,0.001209078,0.0002305011,0.0001050327,0.001404119,0.02365301,0.0001624052,0.0010787,0.1905271],"study_design_scores_gemma":[0.515339,0.418058,0.0521901,0.000239827,0.0012076,0.0008098084,0.00005519718,0.001544602,0.007063255,0.0004091182,0.003047202,0.00003623201],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722765,0.02351235,0.0006047716,0.0007725836,0.000221206,0.0004880255,0.0003219978,0.0000529252,0.001749624],"genre_scores_gemma":[0.9951213,0.002977023,0.0005059544,0.0003262724,0.0001956269,0.0002620597,0.0002933872,0.00000454316,0.0003138775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003246314,"threshold_uncertainty_score":0.01716834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009888083905451041,"score_gpt":0.2541277349581891,"score_spread":0.244239651052738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}