{"id":"W2138874841","doi":"10.1128/ec.00334-13","title":"Using Aspergillus nidulans To Identify Antifungal Drug Resistance Mutations","year":2013,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Aspergillus nidulans; Biology; Antifungal drug; Antifungal; Drug resistance; Echinocandins; Aspergillus; Drug; Mutation; Fungal protein; Genetics; Microbiology; Computational biology; Saccharomyces cerevisiae; Gene; Amphotericin B; Pharmacology; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004154104,0.0004152176,0.0003113363,0.0007677788,0.0002297762,0.0004196873,0.0004818745,0.0004424489,0.0005876269],"category_scores_gemma":[0.0003520145,0.0002095068,0.0003185108,0.0004566808,0.0002566896,0.0001859197,0.0005054298,0.0005530369,0.0004924292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004325494,"about_ca_system_score_gemma":0.0002566854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002382807,"about_ca_topic_score_gemma":0.003286068,"domain_scores_codex":[0.9995273,0.00007737238,0.00009126507,0.000146506,0.0001131201,0.00004443538],"domain_scores_gemma":[0.9997913,0.00004314589,0.0000475122,0.00005093506,0.00003669022,0.00003037648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003992721,0.00006004666,0.0017083,0.00003506167,0.00001118151,0.0001019605,0.00002073966,0.0001054899,0.9926248,0.0001265937,0.00007387641,0.005092072],"study_design_scores_gemma":[0.00004974829,0.0004098829,0.02795401,0.00002854233,0.0000693372,0.00167257,0.0001564581,0.00312959,0.9540653,0.0003593191,0.01207306,0.00003216402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258643,0.002489658,0.06106844,0.000642644,0.0001653201,0.0006557479,0.003780254,0.0007724583,0.004561035],"genre_scores_gemma":[0.914704,0.001747624,0.07362149,0.0005090353,0.00001972752,0.0002235226,0.005290246,0.000143002,0.003741364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002382807,"threshold_uncertainty_score":0.004737914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937111497571449,"score_gpt":0.3197167034635851,"score_spread":0.2903455884878706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}