{"id":"W2138877935","doi":"10.1074/jbc.m204810200","title":"Prostaglandin E2 Suppresses Chemokine Production in Human Macrophages through the EP4 Receptor","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":338,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute","keywords":"Prostaglandin E2 receptor; Prostaglandin E2; Chemokine; Chemistry; Cell biology; Receptor; CCL21; Production (economics); Chemokine receptor; Biology; Endocrinology; Biochemistry; Agonist; Economics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640037,0.0003854928,0.0003729517,0.0002587171,0.0001318255,0.0002460411,0.0001369888,0.000255751,0.001922699],"category_scores_gemma":[0.0002594854,0.0001504402,0.0003112164,0.0001551685,0.0001655355,0.000143041,0.0001936416,0.0004007169,0.0007294627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266765,"about_ca_system_score_gemma":0.0002545847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002756731,"about_ca_topic_score_gemma":0.00036022,"domain_scores_codex":[0.9997157,0.00009526479,0.00003311124,0.00002561355,0.0000614125,0.00006879035],"domain_scores_gemma":[0.9998989,0.0000295388,0.0000191412,0.00001483269,0.00001792326,0.00001961604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003779252,0.00006837383,0.000143297,0.00004366511,0.000004409637,0.00005741915,0.00001173257,0.00002510913,0.9980378,0.0000270803,0.00004787691,0.001155483],"study_design_scores_gemma":[0.0001080766,0.001579081,0.007108329,0.000009299161,0.0000223926,0.0003515103,0.00003801303,0.0004914349,0.9866698,0.000051881,0.003564597,0.000005492876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923401,0.003360254,0.002023009,0.0001686984,0.00006990338,0.00005831073,0.0004361221,0.00004029263,0.001503298],"genre_scores_gemma":[0.9875171,0.003001314,0.00312641,0.0002885858,0.00009761385,0.0001508821,0.001233449,0.00001580461,0.004569046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922699,"threshold_uncertainty_score":0.006432056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02952251746856456,"score_gpt":0.2741678800570955,"score_spread":0.2446453625885309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}