{"id":"W2138925054","doi":"10.1186/1748-7161-6-26","title":"Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy","year":2011,"lang":"en","type":"article","venue":"Scoliosis","topic":"Birth, Development, and Health","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University","keywords":"Exposome; Epigenetics; Medicine; Perspective (graphical); Scoliosis; Idiopathic scoliosis; Neurology; Bioinformatics; Neuroscience; Pathology; Physiology; Psychiatry; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005720463,0.0001661805,0.000479571,0.000125387,0.0001316246,0.000008207006,0.00006862018,0.0001164915,0.000003678708],"category_scores_gemma":[0.00006293968,0.0001158083,0.00005822169,0.0001832348,0.0007674614,0.00005487886,0.00005136624,0.0001089884,5.666248e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002325799,"about_ca_system_score_gemma":0.0002788162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001628592,"about_ca_topic_score_gemma":0.00001466931,"domain_scores_codex":[0.9986757,0.0001102371,0.0004369449,0.0003033333,0.0002584175,0.0002153385],"domain_scores_gemma":[0.9991441,0.00002484314,0.0002819724,0.0002042847,0.0001833376,0.0001614546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008536706,0.001031253,0.7959806,0.002673535,0.0006123974,0.000006500551,0.01235076,0.000004281261,0.02733706,0.1500064,0.000009760173,0.001450797],"study_design_scores_gemma":[0.005272384,0.001931452,0.9566124,0.0008582533,0.0002667711,0.000163031,0.001261141,0.0001240403,0.02998042,0.003384138,6.46338e-7,0.0001453253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657442,0.02567421,0.005765612,0.001004507,0.00001258486,0.001614281,0.00002529105,0.000007836061,0.000151469],"genre_scores_gemma":[0.9562611,0.03831939,0.004895538,0.0002970301,0.00003457119,0.0001696558,0.000003328933,0.00001904669,3.121734e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1606318,"threshold_uncertainty_score":0.4722527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506193054854843,"score_gpt":0.2616584138158108,"score_spread":0.2365964832672623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}