{"id":"W2139017777","doi":"10.1126/scisignal.2002979","title":"Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock","year":2012,"lang":"en","type":"article","venue":"Science Signaling","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McGill University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Motif (music); Ankyrin repeat; Ankyrin; Sequence motif; Sequence (biology); Cell biology; Biology; Computational biology; Chemistry; Genetics; DNA; Gene; Art","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007149386,0.0001060627,0.00009099251,0.00008050828,0.000170006,0.0000419854,0.0002743169,0.00007030503,0.0001613028],"category_scores_gemma":[0.0001280578,0.0001047081,0.0000487595,0.0002931044,0.0003084942,0.00006453465,0.00007238048,0.00009469977,0.00003373091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000368177,"about_ca_system_score_gemma":0.0000793887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004907329,"about_ca_topic_score_gemma":0.000003722012,"domain_scores_codex":[0.9987792,0.000052122,0.0002150564,0.0003502468,0.0002496334,0.0003536849],"domain_scores_gemma":[0.9991735,0.00001071346,0.0001199509,0.0003408398,0.0002100358,0.0001449898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001278398,0.0000596368,0.0009994252,0.000004870146,0.000004030883,3.081856e-7,0.0001003709,0.0000504833,0.9942971,0.00001619058,0.0002978949,0.004156862],"study_design_scores_gemma":[0.0001009195,0.0001235285,0.0002517553,0.00002848443,0.000005073397,0.0000194945,0.0002254542,0.0000781712,0.995919,0.0001271435,0.002983157,0.0001377704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946916,0.0003816113,0.003339967,0.00003196565,0.0002784773,0.0001411214,0.00002812958,0.00001496227,0.001092233],"genre_scores_gemma":[0.9960515,0.00003394834,0.003378059,0.00005772429,0.0002013339,0.00001776601,0.0000577989,0.00001206347,0.0001897287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004019091,"threshold_uncertainty_score":0.4269871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05250491291052262,"score_gpt":0.3079397729728319,"score_spread":0.2554348600623093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}