{"id":"W2139017777","doi":"10.1126/scisignal.2002979","title":"Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock","year":2012,"lang":"en","type":"article","venue":"Science Signaling","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McGill University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Motif (music); Ankyrin repeat; Ankyrin; Sequence motif; Sequence (biology); Cell biology; Biology; Computational biology; Chemistry; Genetics; DNA; Gene; Art","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225495,0.0002427028,0.0001408615,0.00006479035,0.0001200587,0.000176231,0.0002292751,0.0001790799,0.001487755],"category_scores_gemma":[0.0001691554,0.0001237338,0.0002109219,0.00006136976,0.000136815,0.0001855202,0.0002607109,0.0003395066,0.0006060682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001829761,"about_ca_system_score_gemma":0.0000887027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001439032,"about_ca_topic_score_gemma":0.0002271913,"domain_scores_codex":[0.9998895,0.00002972804,0.00000696819,0.00002689026,0.00002193905,0.0000249745],"domain_scores_gemma":[0.9998881,0.00002418035,0.00003752831,0.00001296176,0.000008305191,0.0000288545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009488549,0.0000148626,0.0004177164,0.0000185883,0.000006790475,0.00007525986,0.00000927601,0.00008944781,0.9983158,0.00006015577,0.00002997567,0.0008672875],"study_design_scores_gemma":[0.0000267374,0.0002743676,0.007006654,0.000003875093,0.00001145758,0.0007957282,0.00002620191,0.003203138,0.987007,0.00005220665,0.001583743,0.000008979461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963539,0.0002862235,0.002794586,0.00003015649,0.000008321794,0.000009907551,0.00003781205,0.00004362413,0.0004354881],"genre_scores_gemma":[0.9969093,0.0000719113,0.002009649,0.00003545982,0.000004445951,0.00000945528,0.0001431612,0.000009561072,0.000807013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487755,"threshold_uncertainty_score":0.004977047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05250491291052262,"score_gpt":0.3079397729728319,"score_spread":0.2554348600623093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}