{"id":"W2139025786","doi":"10.1124/dmd.105.005397","title":"TRANSCRIPTIONAL REGULATION OF THE NAD(P)H:QUINONE OXIDOREDUCTASE 1 AND GLUTATHIONE S-TRANSFERASE YA GENES BY MERCURY, LEAD, AND COPPER","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cycloheximide; NAD+ kinase; Biology; Metallothionein; Glutathione; Molecular biology; Gene expression; Protein biosynthesis; Biochemistry; Gene; Inducer; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405187,0.0002170484,0.0002296862,0.000347348,0.0003115444,0.000367489,0.0001733806,0.0002082658,0.00172421],"category_scores_gemma":[0.0002060243,0.0002083842,0.0002670076,0.0001985954,0.0002874999,0.0001887631,0.0002850659,0.000395502,0.0003705407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006048376,"about_ca_system_score_gemma":0.0003251372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002433552,"about_ca_topic_score_gemma":0.003771764,"domain_scores_codex":[0.9998578,0.00002214887,0.000005751539,0.00004934016,0.00002300745,0.00004202985],"domain_scores_gemma":[0.9997812,0.00005814234,0.00004274076,0.00001909157,0.00005102526,0.0000478337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004800656,0.00003139899,0.002302726,0.00001616579,0.000006840308,0.00006574181,0.00009479007,0.00006047266,0.9943698,0.0003915238,0.0001175415,0.002062967],"study_design_scores_gemma":[0.00007403684,0.0003055902,0.1503587,0.00001559548,0.00003806009,0.0005185647,0.0004040531,0.002679429,0.841637,0.0006351078,0.003313579,0.00002035619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959924,0.0005329367,0.001629968,0.000179366,0.00001974523,0.00001129684,0.0004034215,0.00006060826,0.001170311],"genre_scores_gemma":[0.989976,0.0002356395,0.001111067,0.00007591219,0.00001071037,0.00002163049,0.0008421534,0.0000325892,0.007694279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002433552,"threshold_uncertainty_score":0.005768061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003953296741427582,"score_gpt":0.2025126730764584,"score_spread":0.1985593763350308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}