{"id":"W2139034522","doi":"10.1128/aac.00800-09","title":"Human Immunodeficiency Virus Type 1 Recombinant Reverse Transcriptase Enzymes Containing the G190A and Y181C Resistance Mutations Remain Sensitive to Etravirine","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Etravirine; Efavirenz; Virology; Nevirapine; Reverse transcriptase; Biology; Recombinant DNA; Reverse-transcriptase inhibitor; Nucleotidyltransferase; Mutation; Resistance mutation; Polymerase; Virus; Enzyme; Molecular biology; DNA; Polymerase chain reaction; RNA; Genetics; Gene; Viral load; Biochemistry; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073288,0.0002583328,0.0002212782,0.0001895184,0.0001320104,0.0003818068,0.0001720634,0.0002186313,0.001007309],"category_scores_gemma":[0.0003918826,0.0001606683,0.0002488132,0.0001523646,0.0001672234,0.0001601278,0.0001147416,0.000401376,0.0004954384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542247,"about_ca_system_score_gemma":0.0001394243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007178625,"about_ca_topic_score_gemma":0.0007012449,"domain_scores_codex":[0.9996401,0.0001064225,0.00003778721,0.00004332961,0.000115679,0.00005662295],"domain_scores_gemma":[0.9997779,0.00006342634,0.00006534529,0.0000408865,0.00003021574,0.0000222027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008653673,0.00004420487,0.0007338424,0.0000156314,0.000009147805,0.00004786155,0.00001939459,0.0000681681,0.9971306,0.00008907942,0.00004915849,0.001706427],"study_design_scores_gemma":[0.00002360319,0.0004365681,0.005252424,0.000005783339,0.00001761176,0.000657418,0.0000314939,0.0009372262,0.9899518,0.00005252472,0.002628179,0.000005460813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967567,0.000633213,0.001340993,0.00004733562,0.0000115322,0.00001955999,0.0002178321,0.00002889239,0.0009439032],"genre_scores_gemma":[0.9947802,0.0004365287,0.002085576,0.00004287448,0.000008014452,0.00001598489,0.00116581,0.00002052226,0.001444536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007309,"threshold_uncertainty_score":0.003369808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515860339694517,"score_gpt":0.278089468055972,"score_spread":0.2629308646590268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}