{"id":"W2139107716","doi":"10.1016/j.bpj.2009.12.734","title":"Extracellular K+ Removal Leads to a Complete Conductance Loss that Triggers Internalization of the Cell Surface hERG Channels","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"hERG; Potassium channel; Internalization; Biophysics; Chemistry; Gating; Ion channel; Conductance; Mutant; Repolarization; Cell biology; Electrophysiology; Biochemistry; Cell; Biology; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793464,0.0004096102,0.0008392196,0.0001262301,0.0002204724,0.0004526506,0.0003674406,0.0007222456,0.001679603],"category_scores_gemma":[0.0003241258,0.0002221461,0.0006277433,0.0001462173,0.0004611135,0.000399599,0.0005220984,0.001312541,0.0006291736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004360078,"about_ca_system_score_gemma":0.0003038189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000753533,"about_ca_topic_score_gemma":0.0008977743,"domain_scores_codex":[0.9995493,0.00003326308,0.00003481306,0.00005866661,0.0001192534,0.0002047067],"domain_scores_gemma":[0.9997943,0.00006218748,0.00003366014,0.00005494268,0.00001605892,0.00003884966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004001463,0.00004046969,0.00008045958,0.0000446592,0.00002017231,0.0004148216,0.00002285772,0.0001127552,0.9973787,0.0001876955,0.0001242224,0.001173026],"study_design_scores_gemma":[0.00004931043,0.0002170831,0.00387098,0.000006773344,0.00002326578,0.001027343,0.00005401935,0.0007922476,0.9920163,0.0001606872,0.001768774,0.00001324015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890435,0.001783889,0.004428281,0.000438343,0.0001604312,0.00006254359,0.0006814038,0.0002034049,0.003198097],"genre_scores_gemma":[0.9944106,0.0005847998,0.001517427,0.0002601508,0.00001976142,0.00003144493,0.0006048575,0.00005820687,0.002512759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679603,"threshold_uncertainty_score":0.005618811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907502022776474,"score_gpt":0.2595071740730158,"score_spread":0.240432153845251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}