{"id":"W2139157185","doi":"10.1016/j.jmb.2003.10.056","title":"Structural and Functional Studies of FkpA from Escherichia coli, a cis/trans Peptidyl-prolyl Isomerase with Chaperone Activity","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Centre National de la Recherche Scientifique; Institut national de la recherche scientifique","keywords":"Chaperone (clinical); Periplasmic space; Protein subunit; Prolyl isomerase; Peptidylprolyl isomerase; Dimer; Isomerase; FKBP; Stereochemistry; Mutant; Protein folding; C-terminus; Escherichia coli; Chemistry; Biochemistry; Biology; Crystallography; Amino acid; Enzyme; PIN1; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002128129,0.0001987081,0.0003676661,0.00005423741,0.00005427173,0.000007550318,0.0001129859,0.000148337,0.00002854357],"category_scores_gemma":[0.0002252469,0.0001509645,0.0001221958,0.00008413226,0.0003493514,0.000006870046,0.00004313926,0.0001712931,3.140888e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001541097,"about_ca_system_score_gemma":0.0001479075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008182401,"about_ca_topic_score_gemma":0.00000753822,"domain_scores_codex":[0.9988737,0.0002279676,0.0003015091,0.0002575103,0.000146262,0.0001931117],"domain_scores_gemma":[0.9990113,0.00004466142,0.0003499204,0.0002000509,0.0002762695,0.0001178139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00103591,0.00007100008,0.00592275,0.00001786256,0.0006611695,0.00003442712,0.00007500568,0.0001521461,0.9914854,0.0001102484,0.00004917101,0.0003848996],"study_design_scores_gemma":[0.002112197,0.00185167,0.006086339,0.0000362353,0.0001643144,0.0001059087,0.0001562116,0.00001227006,0.9879984,0.0008636151,0.0004086522,0.0002041998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846669,0.007627149,0.007263883,0.0001038409,0.0001552002,0.0001011175,0.00004604752,0.00000310625,0.00003279519],"genre_scores_gemma":[0.9962959,0.0001919293,0.003169423,0.0001875733,0.0001047705,0.000004888733,0.00001410052,0.00001919095,0.00001218544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01162908,"threshold_uncertainty_score":0.6156154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941589124805235,"score_gpt":0.2704907461005918,"score_spread":0.2510748548525394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}