{"id":"W2139167120","doi":"10.1002/anie.200805642","title":"Efficient Solid‐Phase Synthesis of Sulfotyrosine Peptides using a Sulfate Protecting‐Group Strategy","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Hydrogenolysis; Protecting group; Chemistry; Solid-phase synthesis; Residue (chemistry); Peptide synthesis; Combinatorial chemistry; Yield (engineering); Group (periodic table); Peptide; Stereochemistry; Phase (matter); Organic chemistry; Catalysis; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778094,0.0005198992,0.0003542416,0.0001686507,0.0001332,0.0002224335,0.0002721549,0.0003301329,0.001235873],"category_scores_gemma":[0.0001221703,0.0002089004,0.000251064,0.0001648811,0.0001705476,0.0002352587,0.0002921414,0.0004849575,0.0008259959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802513,"about_ca_system_score_gemma":0.0002853065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002207404,"about_ca_topic_score_gemma":0.0004222154,"domain_scores_codex":[0.9999002,0.00001295127,0.00001052965,0.00002035735,0.00003103906,0.0000250057],"domain_scores_gemma":[0.999905,0.00001790062,0.00002465491,0.00001410864,0.0000155359,0.00002281671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002780102,0.00001055361,0.00001563884,0.00002912128,0.000002511655,0.00003768063,0.000007426325,0.00009742902,0.9982838,0.0001034355,0.00004563411,0.001338947],"study_design_scores_gemma":[0.00001048751,0.00009608705,0.0001154944,0.000001396465,0.000003258942,0.00008382548,0.000002940406,0.0005494763,0.9977506,0.00002893336,0.00135525,0.000002383231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9470013,0.001295593,0.04592537,0.0001671009,0.0001096088,0.0001513765,0.0008159119,0.0003666879,0.00416693],"genre_scores_gemma":[0.9466338,0.001147163,0.04679954,0.00005518086,0.00002636163,0.00009124094,0.001078857,0.00006815577,0.004099606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235873,"threshold_uncertainty_score":0.004134417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648893628927976,"score_gpt":0.304610731624997,"score_spread":0.2881217953357172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}