{"id":"W2139191591","doi":"10.1093/annonc/mds323","title":"Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations","year":2012,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Clinical trial; Oncology; Chemotherapy; Adjuvant chemotherapy; Disease; Precision medicine; Internal medicine; Bioinformatics; Cancer; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03761301,0.001355891,0.003227955,0.001320747,0.00076443,0.003900845,0.002012303,0.002914745,0.006525945],"category_scores_gemma":[0.0549911,0.0004485261,0.001659252,0.002142756,0.002728137,0.002513477,0.001355697,0.003913823,0.001376447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001201808,"about_ca_system_score_gemma":0.003939858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438093,"about_ca_topic_score_gemma":0.002268438,"domain_scores_codex":[0.9908553,0.0069176,0.0007128271,0.0005469293,0.0006697185,0.0002975613],"domain_scores_gemma":[0.9474069,0.03865125,0.003262824,0.003744371,0.004649496,0.002285166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.02311895,0.001367667,0.02930749,0.001363118,0.001626042,0.0001316358,0.0003254464,0.002168202,0.00291181,0.01073148,0.04605731,0.8808907],"study_design_scores_gemma":[0.05710296,0.0756973,0.1217528,0.01565035,0.01051844,0.001444782,0.002841306,0.01731968,0.01536803,0.1171719,0.5643442,0.000788287],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1767345,0.4151064,0.01731995,0.3291414,0.01189803,0.003122155,0.006237451,0.0003137925,0.04012631],"genre_scores_gemma":[0.6441214,0.1763067,0.04047132,0.1006975,0.01605827,0.003815938,0.00522374,0.0004676655,0.0128375],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03761301,"threshold_uncertainty_score":0.1989189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1523871034459548,"score_gpt":0.4523130633149529,"score_spread":0.2999259598689981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}