{"id":"W2139191591","doi":"10.1093/annonc/mds323","title":"Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations","year":2012,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Clinical trial; Oncology; Chemotherapy; Adjuvant chemotherapy; Disease; Precision medicine; Internal medicine; Bioinformatics; Cancer; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000495778,0.00008933566,0.0003336252,0.00005386839,0.00003839544,0.000005337577,0.00006772868,0.000105935,0.00001014116],"category_scores_gemma":[0.0006599505,0.0000824851,0.00009903003,0.00005227542,0.00003012743,0.00000247374,0.00004382605,0.0000219103,0.000001813992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001056619,"about_ca_system_score_gemma":0.00008576711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001858748,"about_ca_topic_score_gemma":0.0000259515,"domain_scores_codex":[0.9992403,0.00005894063,0.0002992064,0.0001468363,0.00003778917,0.0002168906],"domain_scores_gemma":[0.9992629,0.0001700736,0.0001555683,0.0001326179,0.0001687443,0.0001100729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001348003,0.0007131857,0.04985186,0.0000329414,0.0004805622,1.208125e-7,0.0003466068,0.0002111577,0.666073,0.0003910791,0.1030904,0.1774611],"study_design_scores_gemma":[0.001967445,0.003318831,0.08943886,0.000004286635,0.00007942702,0.000001396574,0.00002775413,0.00001874549,0.2168939,0.0002070199,0.6878716,0.0001707842],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945505,0.002002125,0.001494511,0.0007728191,0.0001590639,0.0004349666,0.0002177446,0.000002661686,0.0003655869],"genre_scores_gemma":[0.9946831,0.0009397253,0.001769267,0.00202389,0.0003279277,0.00005080544,0.0001443311,0.00001368237,0.00004720653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5847812,"threshold_uncertainty_score":0.3363645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1523871034459548,"score_gpt":0.4523130633149529,"score_spread":0.2999259598689981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}