{"id":"W2139191939","doi":"10.1371/journal.pone.0001314","title":"Identification of Novel High-Frequency DNA Methylation Changes in Breast Cancer","year":2007,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McGill University","funders":"","keywords":"DNA methylation; Epigenetics; Breast cancer; Biology; Carcinogenesis; Methylation; Cancer; Cancer research; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003998216,0.00007168633,0.0001047521,0.00008687722,0.00001869051,0.000005873515,0.00007564371,0.0001060129,0.0000157784],"category_scores_gemma":[0.00004381448,0.00007719803,0.00001941608,0.000143084,0.00002550032,0.000003733514,0.00002163378,0.00004124241,0.000001387085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002177482,"about_ca_system_score_gemma":0.00002387978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001499312,"about_ca_topic_score_gemma":0.0007309443,"domain_scores_codex":[0.9992735,0.00001841032,0.000244401,0.0001823103,0.0001561414,0.0001252173],"domain_scores_gemma":[0.9994779,0.00001119829,0.0001484776,0.0001837189,0.0001489147,0.00002985451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002388135,0.0003928252,0.02244658,0.00003392362,0.00003205876,1.728609e-7,0.00003898864,0.00002886432,0.9746053,0.0001120049,0.000001293999,0.002284094],"study_design_scores_gemma":[0.0002564848,0.00003055353,0.1919274,0.00002491512,0.00002036536,1.349101e-7,0.00001121555,0.00006781381,0.8074678,0.0001173563,0.000006772575,0.00006918157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960467,0.0007345242,0.002543184,0.0003065243,0.0000450399,0.0001512298,0.00005180465,0.000004884643,0.0001161109],"genre_scores_gemma":[0.9977162,0.0006392706,0.001261681,0.00002442831,0.0001512042,0.00001686397,0.00008967871,0.00001221466,0.00008844884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1694809,"threshold_uncertainty_score":0.3148044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03069287847133951,"score_gpt":0.2710481629849117,"score_spread":0.2403552845135722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}