{"id":"W2139195068","doi":"10.1089/hum.2005.16.1241","title":"Silencing and Variegation of Gammaretrovirus and Lentivirus Vectors","year":2005,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gammaretrovirus; Gene silencing; Retrovirus; Lentivirus; Provirus; Biology; Vector (molecular biology); RNA interference; Viral vector; Virology; Genetics; Gene; Virus; Genome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004234488,0.0003986447,0.0007491268,0.0001872665,0.0001320636,0.00004070779,0.0002419001,0.0003436021,0.0000708752],"category_scores_gemma":[0.00001417332,0.0003579985,0.0001912466,0.0001186158,0.0002020113,0.00000557661,0.000113595,0.0002036843,0.000004369846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003176801,"about_ca_system_score_gemma":0.0001579611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002487657,"about_ca_topic_score_gemma":0.00006365683,"domain_scores_codex":[0.9981885,0.0002757782,0.0004450836,0.0005736203,0.0002171255,0.000299885],"domain_scores_gemma":[0.9990037,0.00002988208,0.0002802074,0.0005190459,0.00006980883,0.00009734042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001476024,0.00004199775,0.00002313616,0.0005876127,0.0002477222,0.000002014369,0.00006037309,8.504355e-7,0.1335274,0.00001156486,0.00005744167,0.8652923],"study_design_scores_gemma":[0.001743765,0.005829036,0.0001770944,0.001014861,0.0002306263,0.00006662574,0.00002287787,0.000003529034,0.1869224,0.00008898646,0.802817,0.001083261],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2104577,0.7888995,0.00001547794,0.000002789192,0.0000373256,0.0004567139,0.00003450847,0.00001032204,0.00008563283],"genre_scores_gemma":[0.01636953,0.9824927,0.0000795345,0.00002968471,0.0004049937,0.00005719669,0.0002044204,0.00009074505,0.0002711929],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8642091,"threshold_uncertainty_score":0.9998872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06424635041458615,"score_gpt":0.3672373616082265,"score_spread":0.3029910111936404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}