{"id":"W2139195068","doi":"10.1089/hum.2005.16.1241","title":"Silencing and Variegation of Gammaretrovirus and Lentivirus Vectors","year":2005,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":382,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gammaretrovirus; Gene silencing; Retrovirus; Lentivirus; Provirus; Biology; Vector (molecular biology); RNA interference; Viral vector; Virology; Genetics; Gene; Virus; Genome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003573849,0.0008514824,0.0008378573,0.00142711,0.0001926159,0.0007062269,0.0007676763,0.0007479286,0.001333808],"category_scores_gemma":[0.000269463,0.0002535385,0.0003105276,0.001482149,0.0003967711,0.0008142188,0.0003656693,0.001014739,0.002087588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006903033,"about_ca_system_score_gemma":0.0004952883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388635,"about_ca_topic_score_gemma":0.0006731562,"domain_scores_codex":[0.9997953,0.00002790447,0.00002303005,0.00003878522,0.0001004934,0.0000146246],"domain_scores_gemma":[0.9999181,0.000028252,0.00001466057,0.000005686967,0.00002445173,0.000008811676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006874945,0.00006452589,0.0001859768,0.00770699,0.00005403009,0.0005079092,0.0001353085,0.000683907,0.04781609,0.01144336,0.01190306,0.9194301],"study_design_scores_gemma":[0.00001390512,0.00009314412,0.000605966,0.0006290794,0.00003448476,0.001711315,0.00004610955,0.0001457917,0.01320123,0.002336437,0.9811644,0.00001812816],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009224664,0.990931,0.002074705,0.0001749166,0.0003130615,0.00001813703,0.00002724927,0.00004394667,0.005494487],"genre_scores_gemma":[0.003776498,0.9886404,0.001696497,0.0002159782,0.0001275531,0.00003018396,0.0000832128,0.000007563043,0.005422137],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00142711,"threshold_uncertainty_score":0.005008459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06424635041458615,"score_gpt":0.3672373616082265,"score_spread":0.3029910111936404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}