{"id":"W2139220626","doi":"10.1128/mcb.22.20.7120-7133.2002","title":"Repression by Homeoprotein Pitx1 of Virus-Induced Interferon A Promoters Is Mediated by Physical Interaction and <i>trans</i> Repression of IRF3 and IRF7","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Centre National de la Recherche Scientifique","keywords":"IRF7; IRF3; Biology; Interferon regulatory factors; Repressor; Psychological repression; Promoter; Transcription factor; IRF1; Hypersensitive site; Molecular biology; Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049202,0.0002558756,0.0001599594,0.000113827,0.0001468361,0.0003019494,0.0001690796,0.0001576479,0.001875391],"category_scores_gemma":[0.0001320905,0.0001584463,0.000209121,0.00007159815,0.0002876702,0.0001955313,0.0003141982,0.0004831324,0.0005671859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770712,"about_ca_system_score_gemma":0.0001693773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002492596,"about_ca_topic_score_gemma":0.0004287791,"domain_scores_codex":[0.9998754,0.00001808268,0.000005309742,0.00002541555,0.00003590537,0.0000397625],"domain_scores_gemma":[0.9999127,0.00001951414,0.00003053673,0.00001056756,0.000006484418,0.00002025677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005724041,0.00001178911,0.0002640608,0.00001416159,0.000001846329,0.00002623108,0.000006967905,0.00002987267,0.9982079,0.0001528892,0.00002439101,0.001202506],"study_design_scores_gemma":[0.00001115595,0.000104184,0.006845367,0.0000045975,0.000005987436,0.0002553577,0.00001992594,0.00108302,0.9897883,0.00009146365,0.001788475,0.000002168729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950388,0.001132729,0.001943331,0.00007336304,0.0000146036,0.00000724794,0.000116202,0.00004274835,0.001631032],"genre_scores_gemma":[0.9943711,0.0005878053,0.001352517,0.00003370938,0.00001260784,0.0000179612,0.0004947335,0.00001917917,0.003110434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001875391,"threshold_uncertainty_score":0.006273866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308200113443429,"score_gpt":0.2551642746926785,"score_spread":0.2420822735582442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}