{"id":"W2139220626","doi":"10.1128/mcb.22.20.7120-7133.2002","title":"Repression by Homeoprotein Pitx1 of Virus-Induced Interferon A Promoters Is Mediated by Physical Interaction and <i>trans</i> Repression of IRF3 and IRF7","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Centre National de la Recherche Scientifique","keywords":"IRF7; IRF3; Biology; Interferon regulatory factors; Repressor; Psychological repression; Promoter; Transcription factor; IRF1; Hypersensitive site; Molecular biology; Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009593007,0.0001620298,0.000377278,0.00008287689,0.00003815415,0.000006793395,0.00003988385,0.0001492697,0.00006733],"category_scores_gemma":[0.00004486234,0.0001289522,0.00006976286,0.00008221954,0.000136436,0.00004887456,0.00005248163,0.0002098946,7.737422e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009378464,"about_ca_system_score_gemma":0.000005398037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001746778,"about_ca_topic_score_gemma":0.000001148502,"domain_scores_codex":[0.9989804,0.0001087941,0.0002951784,0.0003835293,0.00009077881,0.0001412941],"domain_scores_gemma":[0.9994469,0.00003863294,0.0001570023,0.00020958,0.00005273845,0.00009513986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002500066,0.0002500266,0.0001751802,0.00009476791,0.00006057605,0.000006938082,0.0007837786,1.752121e-7,0.991041,0.000009892126,0.0004164329,0.006911248],"study_design_scores_gemma":[0.001048916,0.001709804,0.00003615162,0.0002392316,0.00008659504,0.00003654735,0.000105256,0.00159615,0.9933957,0.00004189642,0.001591609,0.0001120832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943057,0.002372571,0.002321668,0.0004113047,0.00005151927,0.0002801616,0.00005195053,0.0000162429,0.0001888464],"genre_scores_gemma":[0.9992831,0.0003482963,0.00005414752,0.0001267015,0.00001814619,0.00001318491,0.00009577056,0.00001668453,0.00004398285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006799164,"threshold_uncertainty_score":0.5258517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308200113443429,"score_gpt":0.2551642746926785,"score_spread":0.2420822735582442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}