{"id":"W2139230560","doi":"10.1158/0008-5472.can-05-2159","title":"Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Cyclin D; Cyclin-dependent kinase; Cyclin-dependent kinase 6; Cyclin D1; Cancer research; Cyclin D3; Retinoblastoma protein; Cyclin B; Cyclin A2; Cyclin A; Cyclin E; Cyclin D2; Biology; Cyclin; Cell biology; Cell cycle; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002008558,0.0006403465,0.0008666306,0.001083992,0.0006222629,0.0002418686,0.0003636233,0.0004283179,0.0002844601],"category_scores_gemma":[0.001313162,0.0005801384,0.0001309049,0.0007729559,0.000628662,0.0005776539,0.0007890378,0.001658817,0.00008957657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001218344,"about_ca_system_score_gemma":0.0005823777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002374277,"about_ca_topic_score_gemma":0.003735423,"domain_scores_codex":[0.9926991,0.0008655685,0.0009908959,0.001654699,0.001966838,0.001822842],"domain_scores_gemma":[0.99643,0.0009276573,0.0002453204,0.0008700699,0.0004360231,0.001090913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006393407,0.002001098,0.1701386,0.001140983,0.0001933654,0.001567378,0.002416074,0.0002069492,0.6661579,0.00003632421,0.00009967652,0.1496482],"study_design_scores_gemma":[0.01665301,0.001521836,0.268994,0.001442316,0.00005587369,0.00006874804,0.001694466,0.009029572,0.6989202,0.0004469688,0.0004848184,0.0006882192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880922,0.002760126,0.00003899321,0.002833203,0.00008440491,0.005318023,0.00009847931,0.0001344542,0.0006401427],"genre_scores_gemma":[0.9925629,0.000946043,0.001503272,0.00007720001,0.0005365005,0.00153431,0.00009087474,0.0001494386,0.002599386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.14896,"threshold_uncertainty_score":0.999665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04217072083472505,"score_gpt":0.3512264233061662,"score_spread":0.3090557024714412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}