{"id":"W2139230560","doi":"10.1158/0008-5472.can-05-2159","title":"Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Cyclin D; Cyclin-dependent kinase; Cyclin-dependent kinase 6; Cyclin D1; Cancer research; Cyclin D3; Retinoblastoma protein; Cyclin B; Cyclin A2; Cyclin A; Cyclin E; Cyclin D2; Biology; Cyclin; Cell biology; Cell cycle; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651935,0.0002298326,0.0003564813,0.0002588456,0.000213066,0.000301893,0.0001788285,0.0001701827,0.001201664],"category_scores_gemma":[0.0001333957,0.0001812511,0.0002276907,0.0001497781,0.0001930603,0.0001664135,0.0003520236,0.000453448,0.0004003809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149549,"about_ca_system_score_gemma":0.0002441104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004182401,"about_ca_topic_score_gemma":0.0006173798,"domain_scores_codex":[0.9998319,0.00002358909,0.00001551105,0.00003752424,0.0000452406,0.00004612313],"domain_scores_gemma":[0.9999194,0.00001139261,0.00002062523,0.00001313027,0.000007633041,0.0000277577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001997986,0.00003346493,0.0009567215,0.00002019654,0.000006069458,0.0001017748,0.00001062722,0.00006727244,0.9969617,0.0001631349,0.00004786056,0.001431399],"study_design_scores_gemma":[0.0000303837,0.0002574367,0.01650118,0.000003404401,0.0000195055,0.000791683,0.00002946268,0.001037706,0.977746,0.0001338267,0.003445145,0.00000430688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914357,0.003820594,0.002651392,0.0001013904,0.00003853123,0.0000181321,0.0001241048,0.0001210241,0.001688994],"genre_scores_gemma":[0.9972741,0.0007323539,0.0006883001,0.00002423098,0.0000100426,0.00001448739,0.0001058509,0.00001130088,0.001139394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201664,"threshold_uncertainty_score":0.004019976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04217072083472505,"score_gpt":0.3512264233061662,"score_spread":0.3090557024714412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}