{"id":"W2139249889","doi":"10.4049/jimmunol.180.12.8093","title":"ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cell biology; Cytotoxic T cell; CD8; T cell; MAPK/ERK pathway; Cancer research; Biology; Signal transduction; Immune system; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532231,0.0004624418,0.0001700907,0.0002495526,0.0002327712,0.000247743,0.000188688,0.0002080362,0.002237935],"category_scores_gemma":[0.0001037729,0.0001152174,0.0001681213,0.0001161097,0.0001764871,0.0002536084,0.0002184323,0.0007404287,0.0005851346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003290492,"about_ca_system_score_gemma":0.0002269949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001615313,"about_ca_topic_score_gemma":0.0002653601,"domain_scores_codex":[0.9998462,0.00002427703,0.000008973898,0.00002221108,0.0000393654,0.00005897657],"domain_scores_gemma":[0.9999279,0.000006943489,0.00002212182,0.000005704378,0.00000961374,0.00002764824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003362094,0.00005822597,0.0001696718,0.00004614389,0.00000467789,0.00005717879,0.0000123866,0.00007529842,0.9975042,0.0001636133,0.00006015911,0.001512375],"study_design_scores_gemma":[0.0000486773,0.0003170573,0.007807253,0.00001040417,0.00001431489,0.0003653944,0.00003544528,0.001126252,0.9872428,0.0002188448,0.002807862,0.000005626456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940192,0.001901157,0.001407263,0.000135204,0.0000334532,0.00002054003,0.0002825158,0.0000847815,0.002116022],"genre_scores_gemma":[0.9954631,0.0005831597,0.0008049263,0.00004000855,0.00001177063,0.00003321098,0.0003941422,0.00001008342,0.002659684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002237935,"threshold_uncertainty_score":0.007486701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357055826431496,"score_gpt":0.2365960099559114,"score_spread":0.2230254516915964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}