{"id":"W2139251954","doi":"10.1124/dmd.30.7.788","title":"Identification of Human Hepatic Cytochrome P450 Sources of N-alkylprotoporphyrin IX after Interaction with Porphyrinogenic Xenobiotics, Implications for Detection of Xenobiotic-Induced Porphyria in Humans","year":2002,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Xenobiotic; Microsome; CYP1A2; Cytochrome P450; CYP3A4; Enzyme; Biochemistry; CYP2B6; CYP2C9; Biology; Isozyme; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347184,0.0001634528,0.0001750564,0.0003887113,0.0002048328,0.0002017407,0.00007409559,0.0002262846,0.001154664],"category_scores_gemma":[0.0004351155,0.0001377754,0.0001389367,0.0002535615,0.0001886717,0.0001545298,0.0001216984,0.0002756818,0.0003373339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001740521,"about_ca_system_score_gemma":0.00009420732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081305,"about_ca_topic_score_gemma":0.000919064,"domain_scores_codex":[0.9999014,0.00003303752,0.000004058028,0.00002021223,0.00001996612,0.00002128844],"domain_scores_gemma":[0.9998497,0.00005031511,0.00003075481,0.00002265856,0.00002463019,0.00002186697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00336955,0.00008191093,0.02327695,0.00005270139,0.00004588717,0.0009692527,0.0001103666,0.00009878196,0.9600335,0.0002321855,0.0001890882,0.01153968],"study_design_scores_gemma":[0.00006639787,0.0007699295,0.217076,0.000008393889,0.0001100176,0.003934982,0.0001382651,0.0009664916,0.7744487,0.0003549602,0.002118035,0.000007909513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952337,0.0009133486,0.002522572,0.00008334637,0.000008637173,0.00001820941,0.0002278162,0.00002177758,0.0009705884],"genre_scores_gemma":[0.9973241,0.0003420909,0.0007305173,0.00002570398,0.00001203915,0.00001314625,0.0003968893,0.000006980697,0.001148432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154664,"threshold_uncertainty_score":0.003862739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04493355716597812,"score_gpt":0.3605573143749616,"score_spread":0.3156237572089834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}