{"id":"W2139317517","doi":"10.1002/bdra.20695","title":"<i>Cecr2</i> mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors","year":2010,"lang":"en","type":"article","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Exencephaly; Biology; Neural tube; Molecular biology; Hox gene; Genetics; Mutant; SWI/SNF; Gene; Transcription factor; Embryo; Chromatin remodeling; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009224824,0.0001713498,0.0003168246,0.0001189077,0.0001719443,0.00003469885,0.0001247314,0.0003903924,0.0000412207],"category_scores_gemma":[0.0006791138,0.000149838,0.0001905896,0.0002020914,0.0007362902,0.00001032078,0.00007646901,0.000469891,0.000003103584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004613982,"about_ca_system_score_gemma":0.0002090445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004108504,"about_ca_topic_score_gemma":0.0001918145,"domain_scores_codex":[0.9977069,0.0005253225,0.0005464273,0.0005331514,0.0002893101,0.0003988139],"domain_scores_gemma":[0.9989017,0.0001510649,0.0001035853,0.0003103687,0.0003322459,0.0002010547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001180062,0.0001342446,0.02089252,0.00006051639,0.00005704346,0.00001587891,0.00008158293,0.00004226144,0.9756621,0.0004679789,0.0002728399,0.002195051],"study_design_scores_gemma":[0.002745372,0.001160935,0.02694656,0.00007808463,0.00007798574,0.0001378763,0.0001320969,0.002104552,0.9307373,0.001564025,0.0338234,0.0004918096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961025,0.0006548621,0.002157912,0.0002225192,0.0002519652,0.0002990479,0.0000217286,0.00001650134,0.0002729525],"genre_scores_gemma":[0.9987621,0.0002239387,0.0004449785,0.0001215676,0.0001488712,0.00003137542,0.0001040256,0.00002300693,0.0001401597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04492478,"threshold_uncertainty_score":0.6110215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06077530325040078,"score_gpt":0.3963088660844628,"score_spread":0.335533562834062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}