{"id":"W2139372806","doi":"10.1038/nature15526","title":"Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder","year":2015,"lang":"en","type":"article","venue":"Nature","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":581,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; U.S. Department of Veterans Affairs","keywords":"Bipolar disorder; Mania; Neuroscience; Lithium (medication); Treatment of bipolar disorder; Dentate gyrus; Induced pluripotent stem cell; Hippocampal formation; Psychology; Prefrontal cortex; Mood stabilizer; Medicine; Psychiatry; Biology; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213573,0.0001629362,0.000348698,0.0003068518,0.0002689714,0.0004993975,0.0001375807,0.0003810746,0.002581609],"category_scores_gemma":[0.000820534,0.0001009844,0.0001372499,0.0002384019,0.0002346881,0.0001981559,0.0002403913,0.0003610308,0.0002351778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298425,"about_ca_system_score_gemma":0.0001275974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002168617,"about_ca_topic_score_gemma":0.003745341,"domain_scores_codex":[0.9998944,0.00002251169,0.00001595119,0.00001223941,0.00002283686,0.00003195378],"domain_scores_gemma":[0.9997967,0.00005562991,0.00004093694,0.00001265728,0.00004608773,0.00004799703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02052758,0.0003670473,0.3841189,0.0003712615,0.0003305806,0.004372778,0.00174699,0.0002950869,0.5458207,0.0002398857,0.0006503256,0.04115885],"study_design_scores_gemma":[0.0001364128,0.001890138,0.9705489,0.00003349722,0.0001190398,0.004393441,0.001576519,0.0004209315,0.01996871,0.0002093057,0.0006887516,0.00001434433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988808,0.0002432124,0.0000498323,0.00005081243,0.00001026841,0.000005019428,0.00006852235,0.000002833449,0.0006887785],"genre_scores_gemma":[0.9993415,0.000124562,0.00004034617,0.0000693192,0.000005441058,0.000006082328,0.00009848271,0.000002673272,0.0003115115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581609,"threshold_uncertainty_score":0.008636296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00979386116508886,"score_gpt":0.2494864966377656,"score_spread":0.2396926354726767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}