{"id":"W2139382674","doi":"10.1128/aac.00242-10","title":"Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in <i>Pseudomonas aeruginosa</i> Is Mediated by the Novel Two-Component Regulatory System ParR-ParS","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Polymyxin; Colistin; Pseudomonas aeruginosa; Polymyxin B; Microbiology; Biology; Antimicrobial; Lipid A; Antibiotics; Antimicrobial peptides; Antibiotic resistance; Operon; Bacteria; Biochemistry; Gene; Genetics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768094,0.0004084002,0.000303803,0.0001619014,0.0001553038,0.0003691797,0.0002014168,0.0002939,0.0006324105],"category_scores_gemma":[0.000206863,0.0001406106,0.0002845993,0.0000939727,0.0002575844,0.0002138239,0.0002789036,0.0007598219,0.0003825646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003106668,"about_ca_system_score_gemma":0.0002546609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006575251,"about_ca_topic_score_gemma":0.0007308822,"domain_scores_codex":[0.9997606,0.00004232081,0.00001537809,0.00005017569,0.00008467662,0.00004697523],"domain_scores_gemma":[0.9998456,0.00004093906,0.00005283392,0.00001981508,0.00001577491,0.00002506969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002523354,0.00001254089,0.0001723964,0.000007440498,0.000001134482,0.00003603418,0.000009494695,0.00001922805,0.9991003,0.00002982442,0.00001377211,0.0005724716],"study_design_scores_gemma":[0.000009247431,0.0002266743,0.00779769,0.000003768899,0.000009463984,0.0006250338,0.00004726526,0.001141615,0.9887946,0.00005315139,0.001281341,0.00001034863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922902,0.0005177398,0.00577679,0.0002543627,0.00002135977,0.00005041011,0.0002590335,0.0001706498,0.0006593075],"genre_scores_gemma":[0.9916585,0.0003532454,0.005595023,0.0001112031,0.00001850647,0.00003956223,0.0005906753,0.00003720393,0.001595974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006575251,"threshold_uncertainty_score":0.002254009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006449319674204221,"score_gpt":0.2207550613859993,"score_spread":0.214305741711795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}