{"id":"W2139382674","doi":"10.1128/aac.00242-10","title":"Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in <i>Pseudomonas aeruginosa</i> Is Mediated by the Novel Two-Component Regulatory System ParR-ParS","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Polymyxin; Colistin; Pseudomonas aeruginosa; Polymyxin B; Microbiology; Biology; Antimicrobial; Lipid A; Antibiotics; Antimicrobial peptides; Antibiotic resistance; Operon; Bacteria; Biochemistry; Gene; Genetics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003129559,0.0003042385,0.0002750982,0.00003201333,0.0002365137,0.0001098852,0.0003722886,0.0001787606,0.00001010253],"category_scores_gemma":[0.00001820586,0.0002081707,0.00005887972,0.0001333427,0.0003696562,0.000009384033,0.0001266801,0.0002134506,0.00000555939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002036885,"about_ca_system_score_gemma":0.00005018115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001556675,"about_ca_topic_score_gemma":0.0007217285,"domain_scores_codex":[0.9984771,0.00006683329,0.0003445296,0.0005569588,0.0001652303,0.0003893184],"domain_scores_gemma":[0.9991159,0.00003470061,0.0001638472,0.0005139878,0.00006155475,0.0001099476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747497,0.00009835105,0.0219337,0.00003116186,0.00006901075,0.00000392547,0.0003099659,0.000002703205,0.9183062,0.0001302895,0.05841811,0.0003218359],"study_design_scores_gemma":[0.003730315,0.0001372657,0.23495,0.0002305664,0.00004365344,0.00007235204,0.0005404878,0.0001246281,0.5464029,0.000007359763,0.2129999,0.0007605295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944963,0.0001614669,0.0002122998,0.003857432,0.0002650152,0.0005643757,0.0002218774,0.00001440485,0.0002067998],"genre_scores_gemma":[0.9908106,0.0004303367,0.0005120618,0.007501568,0.0001846159,0.000002914105,0.00004983256,0.00004491169,0.0004631289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3719033,"threshold_uncertainty_score":0.8488954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006449319674204221,"score_gpt":0.2207550613859993,"score_spread":0.214305741711795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}