{"id":"W2139389713","doi":"10.1126/scisignal.2005283","title":"Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein–mediated stimulation of T-type calcium channels","year":2014,"lang":"en","type":"article","venue":"Science Signaling","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Michael Smith Health Research BC; University of British Columbia","funders":"","keywords":"Stimulation; Peripheral; Calcium; Insulin; Voltage-dependent calcium channel; Endocrinology; Insulin-like growth factor; Growth factor; Internal medicine; Calcium channel; T-type calcium channel; Medicine; Chemistry; Neuroscience; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063021,0.0004062077,0.0002536202,0.0001889222,0.0001234098,0.0002100116,0.000164688,0.0002409641,0.001246817],"category_scores_gemma":[0.0001314844,0.0001309676,0.0004311146,0.0002275032,0.0003332784,0.0002139369,0.0002248814,0.000760617,0.0001994593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704113,"about_ca_system_score_gemma":0.0001173385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005247651,"about_ca_topic_score_gemma":0.0006072451,"domain_scores_codex":[0.9998984,0.00001530431,0.000005810112,0.00002240119,0.00002054907,0.0000374548],"domain_scores_gemma":[0.9999164,0.000007977392,0.00003482189,0.000008096491,0.000008623118,0.00002414634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004734083,0.00003746777,0.0002236636,0.00007292774,0.000005310802,0.0001089345,0.000008743674,0.00002893642,0.997311,0.00004808952,0.00006289253,0.001618537],"study_design_scores_gemma":[0.0007638886,0.00470012,0.1370045,0.00009145898,0.0001743109,0.002110533,0.0001398811,0.004057541,0.8458623,0.0005922607,0.004471799,0.00003134574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896104,0.005656325,0.002068011,0.0002694759,0.00008918634,0.00003166349,0.0001818607,0.0001203388,0.001972739],"genre_scores_gemma":[0.9941692,0.003209861,0.001142303,0.0001532695,0.00005226482,0.00004263253,0.0001694867,0.00001240862,0.00104852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246817,"threshold_uncertainty_score":0.004171014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610526579247508,"score_gpt":0.2919234384496104,"score_spread":0.2658181726571354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}