{"id":"W2139423334","doi":"10.1189/jlb.1102582","title":"LF15-0195 generates tolerogenic dendritic cells by suppression of NF-κB signaling through inhibition of IKK activity","year":2003,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Roche Organ Transplant Research Foundation; London Health Sciences Centre; Lawson Health Research Institute","keywords":"Biology; Tumor necrosis factor alpha; CD40; CD86; Lipopolysaccharide; Cell biology; IκB kinase; Kinase; Phosphorylation; Signal transduction; Immunology; Cancer research; In vitro; NF-κB; T cell; Immune system; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406081,0.000315885,0.0002457769,0.000198024,0.0001158258,0.0003408978,0.0002228736,0.0001951749,0.000919523],"category_scores_gemma":[0.00009626686,0.0001057438,0.0002232822,0.000143906,0.0002135135,0.0001592897,0.000184964,0.0006192984,0.0003070503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972354,"about_ca_system_score_gemma":0.0001850805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001718602,"about_ca_topic_score_gemma":0.0001926626,"domain_scores_codex":[0.9998914,0.00001612104,0.0000181964,0.00001714172,0.00002309162,0.00003400414],"domain_scores_gemma":[0.9999088,0.00001291732,0.00003249799,0.00001451986,0.00000498895,0.00002620325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575907,0.00008328612,0.0001511518,0.00004195977,0.000006405668,0.00005327679,0.00001395869,0.0001015838,0.997416,0.00009806963,0.00002238998,0.001854301],"study_design_scores_gemma":[0.00008079427,0.000956727,0.001553932,0.000009533879,0.00002310201,0.0003054173,0.00001944841,0.0005844845,0.99457,0.00005432228,0.001837915,0.000004427006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964319,0.0008348163,0.001377578,0.00005434779,0.00002202138,0.00002859833,0.000146372,0.00006404101,0.00104029],"genre_scores_gemma":[0.997686,0.0004267361,0.0009258607,0.00003959779,0.000009932547,0.00003073925,0.0002115278,0.000008485207,0.0006609831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000919523,"threshold_uncertainty_score":0.003076077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166978727193262,"score_gpt":0.2603831284557581,"score_spread":0.2436852557364319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}