{"id":"W2139430471","doi":"10.1161/atvbaha.108.182394","title":"Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix","year":2009,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Extracellular matrix; Calcification; Myofibroblast; Cell biology; Chemistry; Mesenchymal stem cell; Matrix (chemical analysis); Pathology; Biology; Fibrosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278822,0.0002589656,0.0002123192,0.0001696254,0.0001863753,0.0004205616,0.0001035576,0.0001762394,0.0005505308],"category_scores_gemma":[0.0004175486,0.0001438601,0.00012085,0.0001443673,0.000249466,0.000194914,0.0002848455,0.0001953131,0.0001558557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002078359,"about_ca_system_score_gemma":0.000195838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003135647,"about_ca_topic_score_gemma":0.0005170484,"domain_scores_codex":[0.9997771,0.00004138334,0.00002949265,0.00003404783,0.00008567471,0.00003230357],"domain_scores_gemma":[0.9996961,0.00008982419,0.000089338,0.00002454519,0.00005066985,0.00004954799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005849619,0.000009384238,0.001203946,0.00003650523,0.000002804659,0.00008123809,0.00004213267,0.00003518939,0.9973683,0.00004839705,0.00001305162,0.001100522],"study_design_scores_gemma":[0.00004103204,0.0005453957,0.07212803,0.00003515667,0.000040925,0.001267316,0.0002942108,0.0019195,0.9202685,0.0002615956,0.003183356,0.00001500388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943598,0.002671676,0.001840002,0.00004358231,0.00001359065,0.00001236022,0.00004605954,0.00002564235,0.0009873169],"genre_scores_gemma":[0.9969665,0.00115555,0.001124299,0.00002289764,0.000009276663,0.00001544361,0.00006427507,0.000006633691,0.0006351689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005505308,"threshold_uncertainty_score":0.001841724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765313750725642,"score_gpt":0.3129816401628481,"score_spread":0.2953285026555916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}