{"id":"W2139435437","doi":"10.1038/emboj.2011.382","title":"MYST protein acetyltransferase activity requires active site lysine autoacetylation","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institute on Aging; Harvard University; Pennsylvania Department of Health","keywords":"Biology; Lysine; Biochemistry; Acetylation; Acetyltransferase; Active site; Acetyltransferases; Histone Acetyltransferases; Transferase; Histone acetyltransferase; Cell biology; Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971386,0.0002842454,0.0003501332,0.0001951081,0.000326907,0.000865179,0.0003902836,0.0003992652,0.002642965],"category_scores_gemma":[0.000387106,0.0003375266,0.0003784598,0.0002212216,0.0004282564,0.0008584833,0.0006055581,0.0006998549,0.001240309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000597887,"about_ca_system_score_gemma":0.0003561601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000678025,"about_ca_topic_score_gemma":0.001770912,"domain_scores_codex":[0.9997197,0.00002060888,0.00003454095,0.00008041234,0.00008036497,0.00006440716],"domain_scores_gemma":[0.9997362,0.00004182483,0.00005559669,0.00005461316,0.00003645383,0.00007521536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002530484,0.00001838304,0.0008776693,0.00002954715,0.000008265319,0.0001735967,0.00001182665,0.00002399655,0.9964162,0.0007600026,0.0001554973,0.00127184],"study_design_scores_gemma":[0.00001560666,0.00006126178,0.01548215,0.000002963623,0.000009619185,0.001254968,0.00002517391,0.000828634,0.9789943,0.0003429993,0.002973549,0.000008916575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851879,0.002926849,0.006043631,0.0004595157,0.0001965215,0.00001915294,0.001176262,0.0002850925,0.003705071],"genre_scores_gemma":[0.9925855,0.00046301,0.001644558,0.0000662305,0.0000275631,0.000008118774,0.001532173,0.00004476391,0.003628094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002642965,"threshold_uncertainty_score":0.008841574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936665092855559,"score_gpt":0.2454580827780924,"score_spread":0.2160914318495368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}