{"id":"W2139435437","doi":"10.1038/emboj.2011.382","title":"MYST protein acetyltransferase activity requires active site lysine autoacetylation","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institute on Aging; Harvard University; Pennsylvania Department of Health","keywords":"Biology; Lysine; Biochemistry; Acetylation; Acetyltransferase; Active site; Acetyltransferases; Histone Acetyltransferases; Transferase; Histone acetyltransferase; Cell biology; Enzyme; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004971814,0.0001545967,0.0001240078,0.0000339407,0.0003095535,0.00004137535,0.0002295162,0.00009473693,0.000281126],"category_scores_gemma":[0.00006520427,0.0001060387,0.0001258682,0.00008068591,0.00009420718,0.00001779016,0.00005579405,0.0003090765,0.00003380502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002210918,"about_ca_system_score_gemma":0.00009851359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002664865,"about_ca_topic_score_gemma":0.00002184576,"domain_scores_codex":[0.9989824,0.0002423355,0.0001668979,0.0001823182,0.0001677239,0.0002583657],"domain_scores_gemma":[0.9993839,0.000009024203,0.0001306693,0.0002773108,0.00009624877,0.0001028626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005434465,0.00007092067,0.00008960826,0.000007391505,0.00007068011,0.000008091662,0.0008055407,0.000005536385,0.9863845,0.0001159873,0.0002805924,0.01161777],"study_design_scores_gemma":[0.0005184495,0.0003481712,0.003206405,0.00002492123,0.00002859592,0.0001864936,0.00008833024,0.00005778339,0.991854,0.0005809767,0.002947403,0.000158538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901386,0.0002196545,0.003690456,0.0004157255,0.0001134201,0.0002849711,0.00002053543,0.00001609874,0.005100465],"genre_scores_gemma":[0.9978963,0.00006935262,0.0004774828,0.0001046755,0.0005418072,0.00002139481,0.00001192705,0.00002149252,0.0008555441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01145923,"threshold_uncertainty_score":0.4324134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936665092855559,"score_gpt":0.2454580827780924,"score_spread":0.2160914318495368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}