{"id":"W2139437231","doi":"10.1016/s0301-472x(00)00170-3","title":"All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells","year":2000,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; University of Illinois at Urbana-Champaign; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Chemistry; Signal transducing adaptor protein; Acute promyelocytic leukemia; Phosphorylation; Promyelocytic leukemia protein; Tyrosine phosphorylation; Cancer research; Jurkat cells; Retinoic acid; Cell biology; Biology; Biochemistry; Immune system; Immunology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959383,0.0002920386,0.0003201261,0.000371398,0.0003237604,0.0004924238,0.0002264745,0.0002365121,0.00156726],"category_scores_gemma":[0.0001972723,0.0001970119,0.0002973248,0.000365463,0.0002518885,0.000279327,0.0003045024,0.0009387275,0.0006796003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006086375,"about_ca_system_score_gemma":0.000314785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118656,"about_ca_topic_score_gemma":0.00167962,"domain_scores_codex":[0.9996973,0.0000575075,0.00003690307,0.00003962396,0.00006607985,0.0001026546],"domain_scores_gemma":[0.9998529,0.00003355122,0.00002669575,0.00003978475,0.00001398503,0.00003315573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005836086,0.00005296755,0.0002766322,0.00003533124,0.000008963355,0.00009466851,0.00002812748,0.0001150231,0.9969206,0.0002803189,0.00009902856,0.001504748],"study_design_scores_gemma":[0.00004634591,0.0001637045,0.002523046,0.000003619618,0.00001320939,0.0001456837,0.00004603874,0.0005015376,0.9941335,0.00006422575,0.002356088,0.000003046574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990864,0.002653626,0.002010201,0.0002500449,0.00005560187,0.00003552393,0.0006883181,0.0001410816,0.003301597],"genre_scores_gemma":[0.9949286,0.0008980585,0.0009275451,0.00005266316,0.000009583543,0.00002763177,0.0007105102,0.00001563315,0.002429712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156726,"threshold_uncertainty_score":0.005243063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0081650850660062,"score_gpt":0.2486573404624094,"score_spread":0.2404922553964033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}