{"id":"W2139440218","doi":"10.1074/jbc.m111.260794","title":"Pharmacological and Genetic Evaluation of Proposed Roles of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK), Extracellular Signal-regulated Kinase (ERK), and p90RSK in the Control of mTORC1 Protein Signaling by Phorbol Esters","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; University of Dundee; University of British Columbia; British Heart Foundation; Heart and Stroke Foundation of Canada","keywords":"mTORC1; Cell biology; MAPK/ERK pathway; Kinase; Ribosomal s6 kinase; Signal transduction; Biology; Protein kinase A; Mitogen-activated protein kinase kinase; Mitogen-activated protein kinase; Phosphorylation; Chemistry; P70-S6 Kinase 1; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004434591,0.0004688044,0.0002224552,0.0004305349,0.0002893326,0.0003877017,0.0006009354,0.0004261437,0.001723195],"category_scores_gemma":[0.0002448269,0.0002396631,0.000459319,0.0002386348,0.00044599,0.0004520523,0.0001632963,0.0007666273,0.0003709332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006307936,"about_ca_system_score_gemma":0.0006095422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005273613,"about_ca_topic_score_gemma":0.0007910026,"domain_scores_codex":[0.999808,0.00003127559,0.00002771007,0.00003524602,0.00005140051,0.00004651521],"domain_scores_gemma":[0.99984,0.00003433359,0.00003631396,0.00001884799,0.00002735037,0.00004316232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003932519,0.0002003887,0.0002390992,0.0001456841,0.00001363675,0.0000989226,0.000008924617,0.0002636276,0.9922222,0.001558099,0.00006584621,0.004790225],"study_design_scores_gemma":[0.0001439565,0.001325489,0.004112763,0.00002846866,0.0001163446,0.0005199647,0.00005591253,0.002343127,0.9817141,0.0004965564,0.009126287,0.00001700474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514834,0.02085105,0.01333237,0.0009771723,0.0002073119,0.0003431938,0.001006592,0.0001539793,0.01164493],"genre_scores_gemma":[0.9547368,0.0219595,0.01635474,0.0002479922,0.00008467836,0.0002774532,0.001561965,0.00003028467,0.004746473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723195,"threshold_uncertainty_score":0.005764663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02632689795179635,"score_gpt":0.2579748915731654,"score_spread":0.231647993621369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}