{"id":"W2139463129","doi":"10.1091/mbc.11.10.3329","title":"Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding","year":2000,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Medical Research Council","keywords":"Telomerase; Telomerase reverse transcriptase; Telomerase RNA component; Biology; RNA; Primer (cosmetics); Telomere; Molecular biology; Biochemistry; DNA; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199168,0.0003171917,0.0001388298,0.0001327593,0.0001120235,0.0002486138,0.00008923915,0.0002357098,0.001459673],"category_scores_gemma":[0.0003312938,0.0001539762,0.0001592113,0.00007957096,0.0002113884,0.0001502444,0.0002001716,0.0003943116,0.0003915833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001272307,"about_ca_system_score_gemma":0.0001799111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002187665,"about_ca_topic_score_gemma":0.0003456991,"domain_scores_codex":[0.9999045,0.00001357245,0.000008608586,0.00002527657,0.0000343721,0.00001369193],"domain_scores_gemma":[0.9998129,0.00004769764,0.00007313601,0.0000199047,0.00001017017,0.0000361703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004816634,0.00001195628,0.0004832128,0.00002293545,0.000006123411,0.0002049485,0.00001489073,0.0001220778,0.9972241,0.0002052675,0.00002491871,0.00163135],"study_design_scores_gemma":[0.00002621554,0.0002984024,0.02790662,0.00001566136,0.00003165851,0.004896073,0.00002048627,0.001335187,0.9605374,0.0004261336,0.004494024,0.00001217912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948611,0.001214548,0.002331481,0.00005714826,0.00001588852,0.00001953643,0.0001325205,0.0001130906,0.001254712],"genre_scores_gemma":[0.9971476,0.0003729831,0.0008966341,0.00002758065,0.000007553235,0.00001231467,0.0002658182,0.00002165517,0.001247769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459673,"threshold_uncertainty_score":0.004883051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867562414089051,"score_gpt":0.2407034284529116,"score_spread":0.2328358660388225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}