{"id":"W2139472998","doi":"10.1053/j.seminoncol.2005.09.008","title":"Gene Therapy of the Typical Multidrug Resistance Phenotype of Cancers: A New Hope?","year":2005,"lang":"en","type":"review","venue":"Seminars in Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"","keywords":"Medicine; Clinical trial; Multiple drug resistance; Mechanism (biology); Genetic enhancement; Phenotype; Bioinformatics; Gene; Drug resistance; Computational biology; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001084408,0.001245009,0.002357381,0.001102133,0.0003321721,0.001327912,0.001786879,0.002280071,0.002634048],"category_scores_gemma":[0.0008128966,0.0002879306,0.000583494,0.001424805,0.001739735,0.002705761,0.0006295281,0.004029208,0.0027017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009374892,"about_ca_system_score_gemma":0.0008395539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008101565,"about_ca_topic_score_gemma":0.001688101,"domain_scores_codex":[0.999797,0.00004782853,0.00001939448,0.00003346742,0.0000731172,0.00002920272],"domain_scores_gemma":[0.9996787,0.0001753893,0.00002652967,0.00002181133,0.0000621641,0.00003530665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002558373,0.0001702519,0.0001908801,0.006106172,0.0001032234,0.0004730338,0.0001135319,0.0005465187,0.009761889,0.02295814,0.1023725,0.856948],"study_design_scores_gemma":[0.00007860133,0.0001521784,0.0003345896,0.0008719155,0.00006070418,0.001443637,0.00006358989,0.0001190816,0.00169681,0.00693324,0.9882153,0.00003040704],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001735489,0.9945522,0.001012514,0.001997639,0.0009815146,0.000005374913,0.00001362995,0.00003531611,0.001228302],"genre_scores_gemma":[0.001156829,0.9948126,0.0007975579,0.001330686,0.0005953343,0.00001351929,0.00002845698,0.000006127187,0.001258917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002634048,"threshold_uncertainty_score":0.008811772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03510222498305252,"score_gpt":0.3532872443673301,"score_spread":0.3181850193842776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}