{"id":"W2139472998","doi":"10.1053/j.seminoncol.2005.09.008","title":"Gene Therapy of the Typical Multidrug Resistance Phenotype of Cancers: A New Hope?","year":2005,"lang":"en","type":"review","venue":"Seminars in Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; McGill University","funders":"","keywords":"Medicine; Clinical trial; Multiple drug resistance; Mechanism (biology); Genetic enhancement; Phenotype; Bioinformatics; Gene; Drug resistance; Computational biology; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979562,0.0002523928,0.0009473655,0.00006727954,0.00001861976,0.000002595038,0.0006878084,0.0006019408,0.0000486382],"category_scores_gemma":[0.00009217698,0.0001772057,0.0003372228,0.0001940771,0.0002062115,0.000002022,0.0001740614,0.0002621398,0.000005189225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383958,"about_ca_system_score_gemma":0.001586005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009610847,"about_ca_topic_score_gemma":0.001164873,"domain_scores_codex":[0.9984485,0.000231695,0.0006064492,0.000372424,0.000110755,0.0002301921],"domain_scores_gemma":[0.9987347,0.00006454578,0.0004834728,0.0006039314,0.00006903603,0.00004428908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002476599,0.00008983564,0.0000256498,0.0003157939,0.0001097749,0.000003724753,0.0001070302,0.000009318806,0.002617342,0.00001684036,0.01007391,0.9863831],"study_design_scores_gemma":[0.0003664955,0.0003301441,0.00002363659,0.001826469,0.00005227852,0.00001015917,0.0000241571,8.687026e-7,0.004478056,0.00002945514,0.9926932,0.000165072],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00397415,0.9939162,0.000008723304,0.00005974904,0.0003397124,0.0003874321,0.0000453759,0.000002248273,0.001266464],"genre_scores_gemma":[0.001111163,0.9948776,0.0008744487,0.000115891,0.0003301569,0.00003442029,0.00004286955,0.0000276594,0.002585754],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986218,"threshold_uncertainty_score":0.7226239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03510222498305252,"score_gpt":0.3532872443673301,"score_spread":0.3181850193842776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}