{"id":"W2139514746","doi":"10.1016/s0960-894x(03)00331-7","title":"Unexpected inhibition of S-adenosyl-l-homocysteine hydrolase by a guanosine nucleoside","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kimberly-Clark (Canada)","funders":"Georgia Institute of Technology","keywords":"Guanosine; Chemistry; Nucleoside; Adenosine; Stereochemistry; Hydrolase; Biochemistry; Inhibitory postsynaptic potential; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001995357,0.0002809401,0.00027636,0.00003224731,0.00006214409,0.00001315958,0.0002309109,0.0002622425,0.0002403145],"category_scores_gemma":[0.000350181,0.0002656869,0.0001303589,0.0002653805,0.0003201432,0.000004738323,0.00008872602,0.0002480247,0.0000119292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004338852,"about_ca_system_score_gemma":0.00009686952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002533973,"about_ca_topic_score_gemma":0.000001099952,"domain_scores_codex":[0.9981229,0.00007087187,0.0003952213,0.0005380891,0.0004336603,0.0004392717],"domain_scores_gemma":[0.9990023,0.00001501518,0.0001455264,0.000479181,0.0001048224,0.0002531295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049759,0.0001421798,0.0001842317,0.0001168612,0.00006939561,0.00003288269,0.00001534772,4.85657e-7,0.9733584,0.000005709982,0.02587317,0.00009636389],"study_design_scores_gemma":[0.001407287,0.0001127534,0.00004955238,0.00006313906,0.00004037669,0.0001202178,0.00004567189,0.000003065412,0.9852449,0.00001163317,0.0126352,0.0002661766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946004,0.001983708,0.0006318534,0.001701119,0.00005516437,0.0001663525,0.00003888625,0.00002517094,0.0007973267],"genre_scores_gemma":[0.9978013,0.000097055,0.0001740696,0.0009689763,0.0001761868,0.00001611215,0.0004315194,0.00004622544,0.000288528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01323797,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00481822668697604,"score_gpt":0.2132956713724633,"score_spread":0.2084774446854873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}