{"id":"W2139529860","doi":"10.1007/0-306-46862-x_28","title":"De novo design of α-helical coiled-coils: The effect on stability of amino acid substitution in the hydrophobic core","year":2005,"lang":"en","type":"book-chapter","venue":"Kluwer Academic Publishers eBooks","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Substitution (logic); Core (optical fiber); Amino acid substitution; Chemistry; Biophysics; Stereochemistry; Crystallography; Materials science; Biochemistry; Computer science; Biology; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005492192,0.0004652894,0.0006362403,0.0002013978,0.000246689,0.0005927439,0.000447263,0.0003518166,0.001237052],"category_scores_gemma":[0.0005566834,0.0004033929,0.0003433874,0.0002177839,0.0002618408,0.0004947289,0.0003431475,0.0009639927,0.000661671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620326,"about_ca_system_score_gemma":0.0002967737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191406,"about_ca_topic_score_gemma":0.0003974381,"domain_scores_codex":[0.9998288,0.00004375632,0.00001957561,0.00004029784,0.00003722188,0.00003041536],"domain_scores_gemma":[0.9997138,0.00008938542,0.00007026798,0.00003201853,0.00005111767,0.00004333429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005771453,0.0001220027,0.0003230608,0.0003774265,0.00004411876,0.0003794889,0.0001196307,0.02398318,0.9269346,0.006805598,0.0008981891,0.03943552],"study_design_scores_gemma":[0.0001231191,0.0007894736,0.0003797878,0.00003369545,0.00006741941,0.0004129262,0.00004297081,0.03378025,0.9383095,0.002334044,0.0236809,0.00004583852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7041318,0.007843966,0.2754187,0.0005477704,0.0007059603,0.0003206402,0.0005720285,0.001077184,0.009381858],"genre_scores_gemma":[0.8348192,0.004849512,0.1503621,0.0002384999,0.0001148011,0.0002215,0.0008359121,0.000372249,0.008186156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237052,"threshold_uncertainty_score":0.00413841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.032385272942201,"score_gpt":0.2548627693870105,"score_spread":0.2224774964448095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}