{"id":"W2139531225","doi":"","title":"Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"XIAP; Apoptosis; Inhibitor of apoptosis; Cancer research; Programmed cell death; Vinorelbine; Biology; In vivo; Cancer cell; DNA fragmentation; Molecular biology; Caspase; Cancer; Cisplatin; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003427016,0.0001684045,0.000188078,0.00006656203,0.00005006877,0.00002976911,0.00006729236,0.0001347564,0.000003093681],"category_scores_gemma":[0.00004684127,0.0001837705,0.00002719578,0.000111711,0.00005563274,0.00001092969,0.00005863513,0.00011904,1.572994e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004160143,"about_ca_system_score_gemma":0.00001985853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007076603,"about_ca_topic_score_gemma":0.00007171592,"domain_scores_codex":[0.9988285,0.0001041304,0.0001611201,0.0004343459,0.00007617645,0.0003957485],"domain_scores_gemma":[0.999649,0.00001403769,0.00007403493,0.0001635699,0.00001724391,0.0000820767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000418181,0.00005031355,0.002644025,0.00003865605,0.00001832757,0.000001541427,0.00005943651,0.000007200839,0.9867543,0.000003552386,0.00002037534,0.01036047],"study_design_scores_gemma":[0.0004790292,0.000009412873,0.007687804,0.00001267421,0.000006693539,0.000001261363,0.00003142646,0.00005780277,0.9912004,0.00001618511,0.0002930686,0.0002042609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980042,0.0009886405,0.00001986328,0.00003963365,0.00007750745,0.0004523915,0.000008223932,0.00001171539,0.0003978269],"genre_scores_gemma":[0.998345,0.0007231808,0.0002658209,0.0002063446,0.00003374925,0.0002883768,0.000002598022,0.00002802394,0.0001069388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01015621,"threshold_uncertainty_score":0.7493944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008971578787280695,"score_gpt":0.2386552204873446,"score_spread":0.2296836417000639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}