{"id":"W2139531225","doi":"","title":"Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"XIAP; Apoptosis; Inhibitor of apoptosis; Cancer research; Programmed cell death; Vinorelbine; Biology; In vivo; Cancer cell; DNA fragmentation; Molecular biology; Caspase; Cancer; Cisplatin; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143064,0.0003514187,0.0001629746,0.0002130067,0.00007417478,0.0001210662,0.00008866185,0.0001930417,0.001209508],"category_scores_gemma":[0.00009007032,0.0001147088,0.0001530845,0.0001002215,0.0001181001,0.00009792529,0.00008176566,0.0003070901,0.0002257288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062956,"about_ca_system_score_gemma":0.0001491903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004253401,"about_ca_topic_score_gemma":0.0006996521,"domain_scores_codex":[0.9999211,0.00001392426,0.000008536141,0.00001831544,0.00001778375,0.00002031267],"domain_scores_gemma":[0.9999411,0.00001632011,0.00002010836,0.000005989875,0.000006951359,0.000009556697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008861811,0.0000363723,0.0001054462,0.00002928065,0.000005821266,0.00001836001,0.000006676859,0.00006761516,0.9974385,0.00005003883,0.00004854048,0.00210475],"study_design_scores_gemma":[0.00004543524,0.001331984,0.001345353,0.000003702769,0.00002289426,0.0001268028,0.000007910579,0.0004670607,0.9943714,0.00002816477,0.002246828,0.000002553185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902452,0.003467859,0.003840024,0.0001035056,0.0000642386,0.00006782095,0.000273753,0.0001460903,0.001791419],"genre_scores_gemma":[0.9918705,0.002276285,0.002782719,0.00007090186,0.00001892422,0.00006000046,0.000498336,0.00001411932,0.00240823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209508,"threshold_uncertainty_score":0.004046202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008971578787280695,"score_gpt":0.2386552204873446,"score_spread":0.2296836417000639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}