{"id":"W2139538863","doi":"10.1093/nar/gku1386","title":"Transient DNMT1 suppression reveals hidden heritable marks in the genome","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University and Génome Québec Innovation Centre; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Génome Québec; Canadian Institutes of Health Research; Deutsches Krebsforschungszentrum; McGill University","keywords":"Biology; Epigenetics; DNA methylation; Genomic imprinting; Genetics; Germline; Imprinting (psychology); Methylation; Embryo; DNMT1; DNA demethylation; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008343555,0.0001791369,0.0001250194,0.0001298044,0.00008027005,0.0002058168,0.0001798973,0.0001604046,0.001165489],"category_scores_gemma":[0.00008335197,0.0001303087,0.0001471794,0.00007376538,0.0001920476,0.0001245982,0.0001957348,0.0004309827,0.0002745963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002354198,"about_ca_system_score_gemma":0.0001545321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004763016,"about_ca_topic_score_gemma":0.001260735,"domain_scores_codex":[0.9999388,0.000006443427,0.000006067419,0.00002051532,0.00001660452,0.00001151776],"domain_scores_gemma":[0.9999397,0.00001348625,0.00001737416,0.0000139131,0.00000424737,0.00001118113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000212743,0.000002511631,0.00009081887,0.000005739676,0.000001743851,0.00001328282,0.000004278986,0.00002232634,0.9991659,0.0001125893,0.000005832888,0.0005537124],"study_design_scores_gemma":[0.000004399193,0.00005412068,0.001801818,0.000001765614,0.000007248286,0.0001006497,0.000008589914,0.0004860572,0.9965631,0.00005010426,0.0009207318,0.000001394111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928856,0.0006837868,0.004824545,0.0000565317,0.00001687959,0.00001006933,0.0003281104,0.000127885,0.001066602],"genre_scores_gemma":[0.9949025,0.0003265539,0.001838813,0.00001834584,0.000003081366,0.000009160065,0.0003096404,0.000024824,0.002566966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165489,"threshold_uncertainty_score":0.003898919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06606497284079531,"score_gpt":0.3547462025716095,"score_spread":0.2886812297308142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}