{"id":"W2139550411","doi":"10.1002/cpt.87","title":"Rational use of medicines in older adults: Can we do better during clinical development?","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"","keywords":"Extrapolation; Bridging (networking); Clinical trial; Regimen; Medicine; Population; Gerontology; Intensive care medicine; Computer science; Environmental health; Internal medicine; Computer security; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.06684331,0.00103795,0.003351877,0.001445817,0.001351824,0.01099381,0.002435581,0.004689372,0.008610813],"category_scores_gemma":[0.2190357,0.0007234266,0.001951783,0.001829596,0.003091542,0.01563885,0.005804736,0.006352782,0.003172028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004239262,"about_ca_system_score_gemma":0.02434359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00769351,"about_ca_topic_score_gemma":0.01189307,"domain_scores_codex":[0.9712161,0.01950474,0.003476637,0.0009741681,0.003819467,0.001008917],"domain_scores_gemma":[0.890875,0.05467384,0.02087633,0.008067464,0.01674544,0.008761953],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001296369,0.001319007,0.03335563,0.005451678,0.0003526173,0.0004550079,0.003497835,0.004098055,0.0004732138,0.02137626,0.06059446,0.8677298],"study_design_scores_gemma":[0.003135459,0.01051689,0.079272,0.06577065,0.001995339,0.001946561,0.01906093,0.01807438,0.003979122,0.216032,0.5791776,0.001039071],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05660217,0.1293638,0.03110308,0.7432884,0.003801957,0.001248174,0.001138443,0.0007938372,0.03266015],"genre_scores_gemma":[0.4886142,0.2288844,0.1668833,0.1014698,0.004907941,0.002585619,0.001443866,0.0003142981,0.004896695],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9331567,"threshold_uncertainty_score":0.3535054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3811203374204423,"score_gpt":0.5203174305524702,"score_spread":0.1391970931320278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}