{"id":"W2139555044","doi":"10.1002/anie.201400218","title":"The Use of Silyl Ketene Acetals and Enol Ethers in the Catalytic Enantioselective Alkylative Ring Opening of Oxa/Aza Bicyclic Alkenes","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Ketene; Silylation; Enantioselective synthesis; Enol; Nucleophile; Chemistry; Bicyclic molecule; Ring (chemistry); Cyclohexene; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007264751,0.0001470455,0.0001926842,0.00009765213,0.00009751183,0.00006094989,0.0002662836,0.00009106508,0.00008250497],"category_scores_gemma":[0.002076347,0.0001057613,0.00007756374,0.0002174666,0.0002295697,0.0003377587,0.00008471186,0.0001753676,0.000001662108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009685436,"about_ca_system_score_gemma":0.00004116279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002477994,"about_ca_topic_score_gemma":0.00004875299,"domain_scores_codex":[0.9986624,0.0000661554,0.0004334353,0.0002422385,0.0004500622,0.0001457505],"domain_scores_gemma":[0.9966964,0.002349814,0.0003920681,0.0002241773,0.0003086145,0.00002889617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376901,0.0001384763,0.009136902,0.0001256269,0.0003264339,0.000002616362,0.003732067,0.001417729,0.9700729,0.004153587,0.001227911,0.009428053],"study_design_scores_gemma":[0.000619739,0.00001888235,0.004643585,0.0001520015,0.00004203991,0.00002341094,0.0006743466,0.002588711,0.9837224,0.001612273,0.005782597,0.00011999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735036,0.0002928175,0.01283238,0.001452602,0.0005830791,0.0002887897,0.0001581743,0.0000384333,0.01085016],"genre_scores_gemma":[0.9984315,0.0001180778,0.0004250754,0.00009024763,0.0003268873,0.0000469382,0.0002186569,0.0000172942,0.0003253346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02492792,"threshold_uncertainty_score":0.431282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04279198074841784,"score_gpt":0.2980068992396567,"score_spread":0.2552149184912389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}