{"id":"W2139560482","doi":"10.1016/s1474-4422(13)70102-9","title":"Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study","year":2013,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Placebo; Tolerability; Multiple sclerosis; Dose-ranging study; Internal medicine; Cohort; Clinical endpoint; Adverse effect; Interim analysis; Randomized controlled trial; Double blind; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012365,0.001971182,0.002848276,0.0004513375,0.0003277549,0.0008173776,0.0007661752,0.001517201,0.004390616],"category_scores_gemma":[0.0009282398,0.0005389898,0.001528443,0.0004155261,0.0009745929,0.001058285,0.0003971912,0.002617477,0.000896153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004741467,"about_ca_system_score_gemma":0.0008107851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007086992,"about_ca_topic_score_gemma":0.001483658,"domain_scores_codex":[0.9997342,0.0001146549,0.00001328163,0.00004219388,0.00002247901,0.00007312467],"domain_scores_gemma":[0.9995347,0.0001271165,0.00007512767,0.00005334471,0.00002675912,0.0001828694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.940597,0.008672401,0.0008259341,0.000777137,0.001247471,0.00007987539,0.00009334461,0.001231115,0.008584826,0.0002081967,0.001005047,0.03667768],"study_design_scores_gemma":[0.9213672,0.07435353,0.002150948,0.00002949714,0.0003365708,0.00004002726,0.00002619228,0.0004470379,0.0004332319,0.0002002075,0.0005955602,0.00002005795],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930733,0.00217948,0.0005811047,0.0004588456,0.0002530391,0.001317386,0.000640082,0.0001243921,0.001372362],"genre_scores_gemma":[0.984498,0.003373814,0.002397395,0.001407394,0.0003759804,0.003195578,0.001198513,0.00004728567,0.003505989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004390616,"threshold_uncertainty_score":0.01468813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038342795681824,"score_gpt":0.2537246030815696,"score_spread":0.2233411751247514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}