{"id":"W2139621538","doi":"10.1128/mcb.00496-12","title":"SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Centre Hospitalier Universitaire de Québec; Moffitt Cancer Center; McGill University; Emory University; National Institute of General Medical Sciences; American Heart Association","keywords":"Histone acetyltransferase; Acetylation; Acetyltransferase; Histone; Lysine; Biology; DNA damage; DNA; DNA repair; PCAF; P300-CBP Transcription Factors; Histone deacetylase; NAD+ kinase; Molecular biology; Cancer research; Biochemistry; Cell biology; Enzyme; Histone Acetyltransferases; Amino acid; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011308,0.0003418408,0.0002700223,0.0001788766,0.0001681862,0.0002471756,0.0002105052,0.000259566,0.002234576],"category_scores_gemma":[0.0001467277,0.0001232194,0.0003044647,0.0001429333,0.0002281771,0.0001919883,0.0002066677,0.0003535025,0.0006529727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760505,"about_ca_system_score_gemma":0.0001003895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367734,"about_ca_topic_score_gemma":0.0006761472,"domain_scores_codex":[0.9998764,0.00001832617,0.000006660017,0.00003315783,0.00003073452,0.00003470311],"domain_scores_gemma":[0.9999025,0.00001090107,0.00003484124,0.00001202246,0.00001372579,0.00002606011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009277154,0.000006538773,0.0007843759,0.00002433943,0.000007722624,0.0000462475,0.000009719486,0.00003636022,0.9968848,0.00008977897,0.00007781342,0.001939503],"study_design_scores_gemma":[0.00002073209,0.0001550183,0.04570381,0.00000646782,0.00002998323,0.0005756599,0.00003947895,0.001024443,0.9467041,0.000182166,0.005548917,0.00000905584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848018,0.006538237,0.00447454,0.0002348733,0.00007516122,0.00001284787,0.00058233,0.0002070193,0.003073134],"genre_scores_gemma":[0.9963408,0.0009931702,0.0005999003,0.00004836477,0.00001399726,0.000005627749,0.0004349854,0.00001574341,0.001547321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234576,"threshold_uncertainty_score":0.007475436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282008465172001,"score_gpt":0.2403003377088366,"score_spread":0.2274802530571166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}