{"id":"W2139651073","doi":"10.1101/gr.185371.114","title":"Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast","year":2015,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust; Wellcome","keywords":"Biology; Exon skipping; RNA splicing; Schizosaccharomyces; Exon; Exosome complex; Genetics; Schizosaccharomyces pombe; Alternative splicing; RNA; Cell biology; Gene; Non-coding RNA; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002385033,0.000103376,0.0001285858,0.0001803868,0.0001132164,0.00007162309,0.0003179625,0.0001294124,0.00002939536],"category_scores_gemma":[0.0007018351,0.00009853885,0.00003749413,0.0003812091,0.00009360344,0.0000105599,0.0002135612,0.0002905439,0.00009204688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001312929,"about_ca_system_score_gemma":0.0001916157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000402409,"about_ca_topic_score_gemma":0.0001102076,"domain_scores_codex":[0.9978763,0.0003862262,0.0001859034,0.0003821983,0.0005574576,0.0006118593],"domain_scores_gemma":[0.9991003,0.00003381646,0.00003035971,0.0003433563,0.0002082853,0.0002838479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000206194,0.00004289811,0.001850847,0.00001543633,0.000008446093,0.00000930376,0.00006920425,0.00003884612,0.9822019,0.00001338539,0.008096011,0.007447493],"study_design_scores_gemma":[0.005781087,0.002312786,0.02483004,0.0001685702,0.000003808461,0.00003795649,0.002966493,0.003600841,0.3605793,0.0002734487,0.5983942,0.001051509],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942401,0.001444455,0.0001674562,0.0004534325,0.00003973733,0.0002576309,0.00001523476,0.00001034169,0.003371633],"genre_scores_gemma":[0.994526,0.0005799294,0.0001852846,0.00003127079,0.0001088734,0.000018465,0.0001591354,0.00002748905,0.004363555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6216226,"threshold_uncertainty_score":0.4018298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207035280214963,"score_gpt":0.3476174543195153,"score_spread":0.2855471015173657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}