{"id":"W2139651073","doi":"10.1101/gr.185371.114","title":"Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast","year":2015,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust; Wellcome","keywords":"Biology; Exon skipping; RNA splicing; Schizosaccharomyces; Exon; Exosome complex; Genetics; Schizosaccharomyces pombe; Alternative splicing; RNA; Cell biology; Gene; Non-coding RNA; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275691,0.0002724527,0.0003093772,0.0002104404,0.000173331,0.0003237083,0.0001221822,0.0001667494,0.0002208338],"category_scores_gemma":[0.0005037815,0.000145592,0.0003887356,0.0002953387,0.0001768653,0.0001428495,0.0001987964,0.0002016415,0.0001271815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891856,"about_ca_system_score_gemma":0.0001800792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131842,"about_ca_topic_score_gemma":0.00163489,"domain_scores_codex":[0.9998645,0.00001120544,0.00001182353,0.00006007564,0.00003846257,0.0000139409],"domain_scores_gemma":[0.9998125,0.00006380779,0.00006104675,0.00001984896,0.00002339417,0.00001945718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002516283,0.00001126922,0.01177458,0.0000971164,0.00004093715,0.000274988,0.00006123595,0.004559225,0.9765752,0.0001254443,0.00006581937,0.00616261],"study_design_scores_gemma":[0.00003330301,0.0003136146,0.1485215,0.00002715698,0.0001337273,0.001272367,0.0002302409,0.08644125,0.7596488,0.0009287562,0.002405809,0.00004347792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956985,0.0002155893,0.003571437,0.000007919401,0.000001433604,0.000003011044,0.0003102089,0.0000931433,0.00009888961],"genre_scores_gemma":[0.9912152,0.0002532687,0.006432005,0.00002112194,0.000001762298,0.00001166137,0.001866346,0.00004674352,0.0001518887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00131842,"threshold_uncertainty_score":0.002621472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207035280214963,"score_gpt":0.3476174543195153,"score_spread":0.2855471015173657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}