{"id":"W2139663853","doi":"10.3324/haematol.2014.117457","title":"The impact of category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes","year":2015,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Janeway Children's Health and Rehabilitation Centre; McMaster University; McMaster Children's Hospital; Alberta Health; University of Alberta; University of British Columbia; Centre Hospitalier Universitaire de Sherbrooke; Queen's University; Centre Hospitalier Universitaire Sainte-Justine; Population Health Research Institute; Children's Hospital of Western Ontario; Children's Hospital of Eastern Ontario; Princess Margaret Cancer Centre; Alberta Children's Hospital; Izaak Walton Killam Health Centre; University of Saskatchewan; Hospital for Sick Children; Health Sciences Centre; CancerCare Manitoba; BC Children's Hospital; Montreal Children's Hospital; University of Toronto","funders":"","keywords":"Bone marrow failure; Cytogenetics; Myelodysplastic syndromes; Cytopathology; Myeloid; Bone marrow; Myeloid leukemia; Somatic evolution in cancer; Medicine; Hematopathology; Pathology; Leukemia; Neoplastic transformation; Immunology; Oncology; Internal medicine; Biology; Cancer; Haematopoiesis; Stem cell; Genetics; Cytology; Chromosome; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005990142,0.000135356,0.0004183731,0.0001416611,0.00005049322,0.000009522919,0.0000535827,0.0001481999,0.000003256795],"category_scores_gemma":[0.0001379257,0.00007256431,0.00002252375,0.0001466262,0.0003445604,0.00003708982,0.00006447873,0.0001695566,7.341391e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006776974,"about_ca_system_score_gemma":0.0002206252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002598602,"about_ca_topic_score_gemma":0.000026569,"domain_scores_codex":[0.9988828,0.0001259157,0.0003765079,0.00017503,0.0002230432,0.000216649],"domain_scores_gemma":[0.9994245,0.0001081119,0.0001195251,0.0001284098,0.00009917939,0.0001202814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007007073,0.0006426731,0.7838757,0.001629563,0.0002029768,0.001642016,0.01856462,0.00002315181,0.09910253,0.00273734,0.0007784067,0.08379395],"study_design_scores_gemma":[0.005995244,0.004803638,0.8925035,0.0005989998,0.0000446237,0.009878553,0.003162964,0.0009432815,0.08050009,0.0007999499,0.0005062635,0.0002628739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967353,0.001683315,0.00002249795,0.000870575,0.000007680655,0.0005234688,0.000005569383,0.0000100429,0.0001415864],"genre_scores_gemma":[0.997597,0.0004428234,0.001874049,0.00001484725,0.00000361619,0.00003046036,0.00001433597,0.000008308016,0.00001452554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1086278,"threshold_uncertainty_score":0.2959087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04833145918210546,"score_gpt":0.3331537975892342,"score_spread":0.2848223384071287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}