{"id":"W2139705125","doi":"10.1371/journal.ppat.1003874","title":"NsrR, GadE, and GadX Interplay in Repressing Expression of the Escherichia coli O157:H7 LEE Pathogenicity Island in Response to Nitric Oxide","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Institut National de la Recherche Agronomique; European Commission","keywords":"Repressor; Operon; Biology; Effector; Transcription (linguistics); Regulation of gene expression; Pathogenicity island; Escherichia coli; Cell biology; Gene; Gene expression; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844645,0.0002261228,0.0002765397,0.0001085516,0.0001124383,0.0002846587,0.0001675933,0.0002202264,0.0004190387],"category_scores_gemma":[0.0001345243,0.0001315431,0.0001471075,0.0000520726,0.0002637614,0.0001131394,0.0003553202,0.0002577384,0.0001329366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001642434,"about_ca_system_score_gemma":0.0001819111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639717,"about_ca_topic_score_gemma":0.0004782505,"domain_scores_codex":[0.9998295,0.00003887575,0.00001541254,0.00002821265,0.00003501834,0.00005293833],"domain_scores_gemma":[0.9998851,0.00002488943,0.00002277753,0.00001197689,0.00001850136,0.0000368545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000790825,0.00001345237,0.0002850791,0.00002023264,0.000002037165,0.00002679551,0.000015051,0.00002386567,0.9991105,0.00005064539,0.000007186682,0.0003660581],"study_design_scores_gemma":[0.00002526393,0.0003356578,0.02363308,0.0000113432,0.00002187977,0.0002087174,0.0001283897,0.001202012,0.9730017,0.00008642508,0.001336567,0.000008953087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982713,0.0006414821,0.0004963191,0.00003873961,0.000007964381,0.000007621012,0.00003981811,0.00001470403,0.0004819867],"genre_scores_gemma":[0.9971374,0.0003278945,0.0009406147,0.00005438658,0.000006000004,0.00001898954,0.0001337359,0.000008779984,0.001372253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004190387,"threshold_uncertainty_score":0.001401842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076609792495147,"score_gpt":0.2621727218781876,"score_spread":0.2514066239532362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}