{"id":"W2139723436","doi":"10.3892/ijo.2013.2132","title":"Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation","year":2013,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Hyundai Hope On Wheels; U.S. Public Health Service; National Center for Research Resources; Barbara Ann Karmanos Cancer Institute; University of South Carolina; National Cancer Institute; National Institutes of Health; Wayne State University; Rally Foundation","keywords":"Ceramide; Dasatinib; Biology; Ceramide synthase; Cancer research; Sphingosine; Sphingolipid; Apoptosis; Cell biology; Biochemistry; Signal transduction; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335833,0.0004128593,0.0008475229,0.0003704321,0.0001653596,0.0002852676,0.0001864082,0.000347777,0.001557611],"category_scores_gemma":[0.0001384335,0.0002117476,0.0005001582,0.0003339607,0.000221557,0.0002284409,0.0002206358,0.0006619075,0.0003426908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003713415,"about_ca_system_score_gemma":0.0003581157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007662541,"about_ca_topic_score_gemma":0.001086584,"domain_scores_codex":[0.9997198,0.00003505318,0.00003494504,0.0000440762,0.0001011299,0.00006497264],"domain_scores_gemma":[0.9998975,0.0000229474,0.00001691824,0.00001778172,0.00001794979,0.0000268611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002595951,0.00006572042,0.0001891729,0.00004456686,0.00001590999,0.00004968706,0.00001358386,0.00007921833,0.9974963,0.00002329992,0.0000416636,0.001721312],"study_design_scores_gemma":[0.00003556339,0.0009035078,0.004889147,0.000002408971,0.00002851944,0.0002710143,0.00002177791,0.0004605253,0.9923629,0.00002074708,0.0009977167,0.000006121052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950389,0.001666011,0.001316577,0.0000680782,0.00004918654,0.00007756289,0.0003171504,0.00005971949,0.001406861],"genre_scores_gemma":[0.9952077,0.0006989933,0.001506475,0.00003421725,0.00001072085,0.00007117422,0.0004301716,0.00001345701,0.002027084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557611,"threshold_uncertainty_score":0.005210757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007665363505403509,"score_gpt":0.2432629254339702,"score_spread":0.2355975619285667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}