{"id":"W2139723436","doi":"10.3892/ijo.2013.2132","title":"Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation","year":2013,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Hyundai Hope On Wheels; U.S. Public Health Service; National Center for Research Resources; Barbara Ann Karmanos Cancer Institute; University of South Carolina; National Cancer Institute; National Institutes of Health; Wayne State University; Rally Foundation","keywords":"Ceramide; Dasatinib; Biology; Ceramide synthase; Cancer research; Sphingosine; Sphingolipid; Apoptosis; Cell biology; Biochemistry; Signal transduction; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945604,0.00009741273,0.000206561,0.00007856732,0.00002901283,0.00001577458,0.0001222742,0.0001025032,0.00002237861],"category_scores_gemma":[0.00007241914,0.0000694293,0.00005143239,0.0000422425,0.0001254815,0.00002243572,0.00003544599,0.00009995143,1.342394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002803548,"about_ca_system_score_gemma":0.0001009252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000227234,"about_ca_topic_score_gemma":0.00003206925,"domain_scores_codex":[0.9991704,0.0001387571,0.0002971446,0.0001158352,0.0001909598,0.00008686542],"domain_scores_gemma":[0.9985148,0.0001635413,0.0006420619,0.0000805524,0.0005584594,0.00004056291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008233967,0.0003413901,0.003376402,0.000007319575,0.00008575071,0.0000038061,0.0004244109,0.00006364517,0.9911708,0.000006501223,0.00001367445,0.003682912],"study_design_scores_gemma":[0.004425781,0.0007484616,0.08169523,0.00002324032,0.00004040617,0.00003601173,0.0001263049,0.001234714,0.911489,0.00006943744,0.00003851545,0.00007294533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998369,0.0004266668,0.0007033392,0.0001292137,0.0001454435,0.0001472598,0.00002028922,0.0000012145,0.00005756932],"genre_scores_gemma":[0.9994012,0.0001598595,0.0002008484,0.0001209,0.00007527343,0.000007515605,0.00001030637,0.000009691339,0.0000143931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07968184,"threshold_uncertainty_score":0.2831245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007665363505403509,"score_gpt":0.2432629254339702,"score_spread":0.2355975619285667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}