{"id":"W2139767356","doi":"10.1093/carcin/bgp336","title":"Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Samsung; National Institutes of Health; Seoul National University","keywords":"Biology; Histone H3; Histone; Cancer research; Epigenetics; Derepression; Histone methyltransferase; Cancer epigenetics; Histone methylation; Carcinogenesis; Histone H4; Chromatin; EZH2; DNA methylation; Cell biology; Genetics; Psychological repression; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086487,0.0001915429,0.0001886778,0.000214344,0.0001415365,0.0002687492,0.0001549454,0.0001476038,0.0009555134],"category_scores_gemma":[0.0001179542,0.0001087382,0.0002561187,0.0001859718,0.0002073874,0.000127535,0.000229222,0.0003304361,0.0002027179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037218,"about_ca_system_score_gemma":0.0002535199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086307,"about_ca_topic_score_gemma":0.001745145,"domain_scores_codex":[0.9998935,0.00001101383,0.00001045035,0.00003129656,0.00002401424,0.00002967292],"domain_scores_gemma":[0.9998698,0.00001718073,0.00004719254,0.00001462948,0.00001531783,0.00003581058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006982959,0.000004326428,0.0004802868,0.00002041399,0.000003271894,0.00003617957,0.00001039697,0.00002217734,0.9986683,0.00003838308,0.00001525158,0.0006311045],"study_design_scores_gemma":[0.000008038098,0.0000535286,0.01832095,0.000002580061,0.000009421816,0.0002019085,0.00003812187,0.0004033881,0.9777086,0.00004433189,0.003205373,0.000003734905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928658,0.001995171,0.003555699,0.00008788646,0.00002424131,0.00001543938,0.0006228522,0.00007476909,0.0007580888],"genre_scores_gemma":[0.9946709,0.0006684253,0.001330307,0.00004797233,0.000005105427,0.00002146233,0.0009663807,0.00002032575,0.00226916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086307,"threshold_uncertainty_score":0.003196537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211246794583768,"score_gpt":0.2568949071903239,"score_spread":0.2347824392444862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}