{"id":"W2139767356","doi":"10.1093/carcin/bgp336","title":"Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Samsung; National Institutes of Health; Seoul National University","keywords":"Biology; Histone H3; Histone; Cancer research; Epigenetics; Derepression; Histone methyltransferase; Cancer epigenetics; Histone methylation; Carcinogenesis; Histone H4; Chromatin; EZH2; DNA methylation; Cell biology; Genetics; Psychological repression; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008648795,0.0001570476,0.0003256904,0.0001231097,0.0002698004,0.00001046076,0.0001550583,0.00009572716,0.00005892551],"category_scores_gemma":[0.0004069601,0.0001262283,0.00006189597,0.0003675981,0.0004154213,0.00009931793,0.00009035197,0.0001145735,0.00000100957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001675107,"about_ca_system_score_gemma":0.00004731665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008503219,"about_ca_topic_score_gemma":0.00002610273,"domain_scores_codex":[0.9987399,0.00006407453,0.0003027275,0.0004505117,0.0002628338,0.0001799502],"domain_scores_gemma":[0.9986976,0.0001576345,0.0003448476,0.0004970135,0.0002197766,0.00008311041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007562883,0.00003527795,0.09409048,0.00003382707,0.00002810454,0.000007638342,0.001002917,0.00000993708,0.9040798,0.0003002486,0.00006233374,0.0002738137],"study_design_scores_gemma":[0.0003041562,0.000023213,0.3783851,0.00001854762,0.00006419367,0.00001899676,0.00008353855,0.00001779376,0.6208743,0.00008740271,0.00003467597,0.00008805098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982706,0.0001993183,0.0001297765,0.0001124222,0.0001852179,0.0001624901,0.00009179137,0.00003533881,0.0008130714],"genre_scores_gemma":[0.9993241,0.00006865962,0.0001402819,0.00005106963,0.00003462121,0.00002644381,0.000001946765,0.0000197371,0.000333118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2842946,"threshold_uncertainty_score":0.5147441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211246794583768,"score_gpt":0.2568949071903239,"score_spread":0.2347824392444862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}