{"id":"W2139819306","doi":"10.1002/gepi.21694","title":"Exploring the Genetic Architecture of Circulating 25‐Hydroxyvitamin D","year":2012,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; U.S. Public Health Service; Broad Institute; Massachusetts Institute of Technology","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Heritability; Genetic architecture; Biology; Quantitative trait locus; Genetics; Genetic association; Missing heritability problem; Vitamin D and neurology; Explained variation; Twin study; Gene; Genotype; Endocrinology; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001775137,0.0002051252,0.0006882324,0.0001324618,0.0001397535,0.000001724258,0.0002142344,0.00008942875,0.00006001852],"category_scores_gemma":[0.006260539,0.0001257191,0.0001792145,0.0002436336,0.0005099191,0.00002931489,0.0002447858,0.0004277945,0.00004455398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004805948,"about_ca_system_score_gemma":0.00004684896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007808699,"about_ca_topic_score_gemma":0.000007455578,"domain_scores_codex":[0.997129,0.0007724038,0.0006625121,0.000287454,0.0002150559,0.0009335715],"domain_scores_gemma":[0.9961234,0.002731044,0.0001870477,0.0006594041,0.00008403868,0.000215034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001000319,0.00007293383,0.8943181,0.000231225,0.000225464,0.00001441386,0.001875199,0.0008323044,0.01337035,0.0002621467,0.0005026038,0.08828527],"study_design_scores_gemma":[0.0003566115,0.0001922165,0.9947309,0.00007189121,0.0000929452,0.0002969801,0.0003141348,0.0002859065,0.0009047023,0.0007754905,0.001867996,0.0001102597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806263,0.01054979,0.004386941,0.002703041,0.0003327783,0.0004376981,0.000003192265,0.00003504404,0.0009251489],"genre_scores_gemma":[0.9751872,0.0007768046,0.02239368,0.0005599443,0.0007547639,0.0001522612,0.000003509742,0.00002975603,0.0001420527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1004128,"threshold_uncertainty_score":0.7494902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1915549012425431,"score_gpt":0.3651434292987125,"score_spread":0.1735885280561693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}