{"id":"W2139819306","doi":"10.1002/gepi.21694","title":"Exploring the Genetic Architecture of Circulating 25‐Hydroxyvitamin D","year":2012,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; U.S. Public Health Service; Broad Institute; Massachusetts Institute of Technology","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Heritability; Genetic architecture; Biology; Quantitative trait locus; Genetics; Genetic association; Missing heritability problem; Vitamin D and neurology; Explained variation; Twin study; Gene; Genotype; Endocrinology; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001487932,0.000370176,0.0003026371,0.0008215268,0.0003793623,0.000801826,0.0004355959,0.0005192073,0.001243452],"category_scores_gemma":[0.003152308,0.0003174589,0.0007753851,0.00110499,0.0004806476,0.0002951642,0.0005099463,0.000421991,0.000136535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057993,"about_ca_system_score_gemma":0.0004593026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008235347,"about_ca_topic_score_gemma":0.006056339,"domain_scores_codex":[0.9986971,0.0004362615,0.00007052497,0.0005387455,0.0001453841,0.0001120268],"domain_scores_gemma":[0.998767,0.0006109696,0.0002898922,0.0001338855,0.00007680483,0.0001214488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005289979,0.0000670544,0.9720029,0.00004124182,0.001038507,0.0004660806,0.0003582676,0.0009875568,0.01158015,0.001470403,0.0002064251,0.01125244],"study_design_scores_gemma":[0.00004166629,0.0001841221,0.9908574,0.00001286723,0.000377719,0.0003173714,0.0001315337,0.005602259,0.0005223978,0.001384197,0.0005534097,0.00001505284],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963304,0.0004786047,0.002379517,0.0001183061,0.00001037609,0.00001456466,0.0001967349,0.00001842222,0.0004531221],"genre_scores_gemma":[0.9985216,0.0001067078,0.001015235,0.0000369614,0.000008396465,0.000008154113,0.0001343468,0.00000414248,0.0001644222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008235347,"threshold_uncertainty_score":0.01637483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1915549012425431,"score_gpt":0.3651434292987125,"score_spread":0.1735885280561693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}