{"id":"W2139820393","doi":"10.1093/protein/gzp038","title":"Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding","year":2009,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Government of Canada; Alfred P. Sloan Foundation","keywords":"Epitope; Gene isoform; Monoclonal antibody; Chemistry; Scrapie; Prion protein; Cell biology; Protease; Antibody; Molecular mimicry; Conformational change; Peptide; Biochemistry; Biology; Enzyme; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726387,0.000138574,0.000129061,0.00008044331,0.00006667105,0.00002467521,0.0000722423,0.0001084375,0.000009731487],"category_scores_gemma":[0.0001038414,0.0001378972,0.00005825073,0.0001251938,0.00001122788,0.00001227913,0.00002105296,0.0001164794,0.000001022245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001574984,"about_ca_system_score_gemma":0.00002498406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005713632,"about_ca_topic_score_gemma":1.953484e-7,"domain_scores_codex":[0.9992827,0.00004722874,0.0001844161,0.0002340549,0.00007188591,0.0001797156],"domain_scores_gemma":[0.9997224,0.0000113005,0.00006673465,0.00009166918,0.00005464408,0.00005324369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001066098,0.00005180686,0.00004081779,0.00002500288,0.00002859951,7.789167e-7,0.00001348045,0.0008117046,0.9693272,0.00006873935,0.000009754152,0.0295155],"study_design_scores_gemma":[0.0003403165,0.0005837088,0.00153286,0.00008260508,0.00001410845,0.00002715277,0.000007859036,0.008189792,0.9878809,0.000103132,0.001058398,0.0001791959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7544171,0.003712765,0.2412945,0.00005989747,0.00004318237,0.0004086783,8.667996e-7,0.0000445293,0.00001850368],"genre_scores_gemma":[0.9860054,0.0005388041,0.01325532,0.00002321082,0.00009350779,0.00003425547,0.00001014411,0.00001238063,0.00002703658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2315883,"threshold_uncertainty_score":0.5623285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140575310655998,"score_gpt":0.2521792929752478,"score_spread":0.2407735398686879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}