{"id":"W2139820393","doi":"10.1093/protein/gzp038","title":"Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding","year":2009,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Government of Canada; Alfred P. Sloan Foundation","keywords":"Epitope; Gene isoform; Monoclonal antibody; Chemistry; Scrapie; Prion protein; Cell biology; Protease; Antibody; Molecular mimicry; Conformational change; Peptide; Biochemistry; Biology; Enzyme; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020477,0.0003099299,0.0002329859,0.0001528848,0.0001130276,0.000211742,0.0002173649,0.0003067714,0.0004826376],"category_scores_gemma":[0.0001605374,0.0001161825,0.0001665732,0.00009814488,0.0002332757,0.0001254203,0.0001787268,0.0003390413,0.0002263912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087172,"about_ca_system_score_gemma":0.00008035974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001280759,"about_ca_topic_score_gemma":0.0001873437,"domain_scores_codex":[0.9997945,0.00004999956,0.00001146528,0.00003956121,0.00006710419,0.00003737658],"domain_scores_gemma":[0.9999093,0.00002211691,0.00002736688,0.00001108055,0.0000110729,0.00001903863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000143129,0.00001063396,0.00005469398,0.000008568046,0.000001527408,0.00002200564,0.000002659137,0.00001955816,0.9995902,0.00003470973,0.000006612342,0.0002344555],"study_design_scores_gemma":[0.000005868618,0.0001907381,0.001720037,0.000001379612,0.00000575602,0.0003631925,0.000003389823,0.0006861261,0.9965171,0.00002581606,0.0004786685,0.000002072321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992191,0.001058039,0.005573513,0.0000507111,0.00001652475,0.0000270858,0.0000390319,0.00006127448,0.0009828152],"genre_scores_gemma":[0.9963717,0.000232062,0.002695187,0.00004414967,0.000006902023,0.00001430831,0.0000538723,0.000007507273,0.0005743261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004826376,"threshold_uncertainty_score":0.00161463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140575310655998,"score_gpt":0.2521792929752478,"score_spread":0.2407735398686879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}